Journal article
Vulvar, vaginal, and perianal intraepithelial neoplasia in women with or at risk for human immunodeficiency virus
Obstetrics and gynecology (New York. 1953), Vol.107(5), pp.1023-1028
05/01/2006
DOI: 10.1097/01.AOG.0000210237.80211.ff
PMID: 16648406
Abstract
OBJECTIVE:
To compare the incidence of vulvar, vaginal, and perianal intraepithelial neoplasia among human immunodeficiency virus (HIV)–infected women with a group of well-matched high-risk HIV-uninfected controls.
METHODS:
A total of 192 HIV-infected and 88 uninfected women at high risk for HIV were followed up prospectively in Providence, Rhode Island during a 6-year period. Pap tests and cervicovaginal lavage for human papillomavirus detection and typing were performed at baseline and every 6 months thereafter. All women referred for colposcopy underwent a full colposcopic evaluation, including the vulvar, vaginal, and perianal regions. Unadjusted hazard ratios with 95% confidence intervals were calculated for development of vulvar, vaginal, and perianal intraepithelial neoplasia using univariable Cox proportional hazards models. An incidence analysis was performed by calculating Kaplan-Meier survival curves for development of intraepithelial neoplasia.
RESULTS:
At baseline, 3 (1.6%) of the 192 HIV-infected women and none of the 88 HIV-uninfected women had vulvar, vaginal, and perianal intraepithelial neoplasia. During the study, 16 of 189 (8.5%) HIV-infected women and 1 of 88 (1.1%) HIV-uninfected women developed vulvar, vaginal, and perianal intraepithelial neoplasia. The incidence of vulvar, vaginal, or anal intraepithelial neoplasia was 1.96 per 100 person years for the HIV-infected women and 0.26 per 100 person-years for the HIV-uninfected women (P = .03).
CONCLUSION:
Human immunodeficiency virus–infected women had more vulvar, vaginal, and perianal intraepithelial lesions compared with HIV-uninfected women. Furthermore, the incidence rates were higher than has been found in HIV-infected women in other similar cohorts.
Details
- Title: Subtitle
- Vulvar, vaginal, and perianal intraepithelial neoplasia in women with or at risk for human immunodeficiency virus
- Creators
- Denise J Jamieson - Centers for Disease Control and PreventionPangaja Paramsothy - Contraception Research and DevelopmentSusan CU-UVIN - Brown UniversityAnn Duerr - Fred Hutch Cancer CenterHIV Epidemiology Research Study Group
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.107(5), pp.1023-1028
- DOI
- 10.1097/01.AOG.0000210237.80211.ff
- PMID
- 16648406
- NLM abbreviation
- Obstet Gynecol
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Publisher
- Elsevier Science
- Language
- English
- Date published
- 05/01/2006
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446543002771
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