Journal article
WNK kinases and essential hypertension
Current opinion in nephrology and hypertension, Vol.17(2), pp.133-137
03/2008
DOI: 10.1097/MNH.0b013e3282f4e4fd
PMID: 18277144
Abstract
The present review summarizes recent literature and discusses the potential roles of WNKs in the pathogenesis of essential hypertension.
WNKs (with-no-lysine [K]) are a recently discovered family of serine-threonine protein kinases with unusual protein kinase domains. The role of WNK kinases in the control of blood pressure was first revealed by the findings that mutations of two members, WNK1 and WNK4, cause Gordon's syndrome. Laboratory studies have revealed that WNK kinases play important roles in the regulation of sodium and potassium transport. Animal models have been created to unravel the pathophysiology of sodium transport disorders caused by mutations of the WNK4 gene. Potassium deficiency causes sodium retention and increases hypertension prevalence. The expression of WNK1 is upregulated by potassium deficiency, raising the possibility that WNK1 may contribute to salt-sensitive essential hypertension associated with potassium deficiency. Associations of polymorphisms of WNK genes with essential hypertension in the general population have been reported.
Mutations of WNK1 and WNK4 cause hypertension at least partly by increasing renal sodium retention. The role of WNK kinases in salt-sensitive hypertension within general hypertension is suggested, but future work is required to firmly establish the connection.
Details
- Title: Subtitle
- WNK kinases and essential hypertension
- Creators
- Chou-Long Huang - Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390-8856, USA. chou-long.huang@utsouthwestern.eduElizabeth KuoRobert D Toto
- Resource Type
- Journal article
- Publication Details
- Current opinion in nephrology and hypertension, Vol.17(2), pp.133-137
- DOI
- 10.1097/MNH.0b013e3282f4e4fd
- PMID
- 18277144
- ISSN
- 1062-4821
- eISSN
- 1473-6543
- Grant note
- DK-59530 / NIDDK NIH HHS DK-54368 / NIDDK NIH HHS DK-002818 / NIDDK NIH HHS
- Language
- English
- Date published
- 03/2008
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094561102771
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