WNKs: protein kinases with a unique kinase domain

Chou Long Huang; Seung Kuy Cha; Hao Ran Wang; Jian Xie; Melanie H Cobb

doi:10.1038/emm.2007.62

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WNKs: protein kinases with a unique kinase domain

Journal article

Open access

Peer reviewed

WNKs: protein kinases with a unique kinase domain

Chou Long Huang, Seung Kuy Cha, Hao Ran Wang, Jian Xie and Melanie H Cobb

Experimental & molecular medicine, Vol.39(5), pp.565-573

10/31/2007

DOI: 10.1038/emm.2007.62

PMID: 18059132

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Abstract

WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyperkalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.

Cell Proliferation

Neoplasms - etiology

Minor Histocompatibility Antigens

Humans

Kidney - enzymology

Molecular Sequence Data

Hypertension - etiology

Pseudohypoaldosteronism - etiology

Hyperkalemia - genetics

WNK Lysine-Deficient Protein Kinase 1

Neoplasms - genetics

Hypertension - enzymology

Hypertension - genetics

Protein-Serine-Threonine Kinases - metabolism

Hyperkalemia - etiology

Protein Structure, Tertiary

Amino Acid Sequence

Signal Transduction

Cell Survival

Pseudohypoaldosteronism - genetics

Hyperkalemia - enzymology

Protein-Serine-Threonine Kinases - genetics

Intracellular Signaling Peptides and Proteins

Models, Molecular

Neoplasms - enzymology

Syndrome

Sequence Homology, Amino Acid

Pseudohypoaldosteronism - enzymology

Animals

Protein-Serine-Threonine Kinases - chemistry

Mutation

Details

Title: Subtitle: WNKs: protein kinases with a unique kinase domain
Creators: Chou Long Huang - Department of Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA. chou-long.huang@utsouthwestern.edu
Seung Kuy Cha
Hao Ran Wang
Jian Xie
Melanie H Cobb
Resource Type: Journal article
Publication Details: Experimental & molecular medicine, Vol.39(5), pp.565-573
DOI: 10.1038/emm.2007.62
PMID: 18059132
NLM abbreviation: Exp Mol Med
ISSN: 1226-3613
eISSN: 2092-6413
Grant note: DK54368 / NIDDK NIH HHS DK59530 / NIDDK NIH HHS GM53032 / NIGMS NIH HHS
Language: English
Date published: 10/31/2007
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094399502771

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