Journal article
Waldenström Macroglobulinemia: Unusual Presentation With Cast Nephropathy/Light Chain Tubulopathy
Clinical medicine insights. Case reports, Vol.12, p.1179547619828704
2019
DOI: 10.1177/1179547619828704
PMCID: PMC6378479
PMID: 30799965
Abstract
Cast Nephropathy/Light chain tubulopathy is usually present in patients with multiple myeloma and is very rare in patients with Waldenstrom Macroglobulinemia. There are very few case reports mentioned in the literature. We present an interesting case of Cast Nephropathy and light chain tubulopathy in an 81-year-old female patient with Waldenstrom Macroglobulinemia who required medical attention for worsening renal failure. Serum protein electrophoresis/Immunofixation showed IgM Kappa monoclonal gammopathy. Renal biopsy was remarkable for cast nephropathy and light chain tubulopathy. Furthermore on bone marrow biopsy a low grade B cell lymphoproliferative disorder with plasmacytic differentiation was present. This was most consistent with lymphoplasmacytic lymphoma, accounting for 50-60 percent of total bone marrow cellularity, in a hypercellular (60-80 percent) bone marrow.
Details
- Title: Subtitle
- Waldenström Macroglobulinemia: Unusual Presentation With Cast Nephropathy/Light Chain Tubulopathy
- Creators
- Muddasir Ashraf - Trinity Medical CenterPrerna Rastogi - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical medicine insights. Case reports, Vol.12, p.1179547619828704
- DOI
- 10.1177/1179547619828704
- PMID
- 30799965
- PMCID
- PMC6378479
- NLM abbreviation
- Clin Med Insights Case Rep
- ISSN
- 1179-5476
- eISSN
- 1179-5476
- Language
- English
- Date published
- 2019
- Academic Unit
- Pathology
- Record Identifier
- 9984186436802771
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