Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genes

Laurival A De Luca; Zhice Xu; Guus H. M Schoorlemmer; Robert L Thunhorst; Terry G Beltz; José V Menani; Alan Kim Johnson

doi:10.1152/ajpregu.00295.2000

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Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genes

Journal article

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Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genes

Laurival A De Luca, Zhice Xu, Guus H. M Schoorlemmer, Robert L Thunhorst, Terry G Beltz, José V Menani and Alan Kim Johnson

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.282(2), pp.R552-R559

02/01/2002

DOI: 10.1152/ajpregu.00295.2000

PMID: 11792666

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Abstract

10.1152/ajpregu.00295.2000. Adult rats deprived of water for 24–30 h were allowed to rehydrate by ingesting only water for 1–2 h. Rats were then given access to both water and 1.8% NaCl. This procedure induced a sodium appetite defined by the operational criteria of a significant increase in 1.8% NaCl intake (3.8 ± 0.8 ml/2 h; n = 6). Expression of Fos (as assessed by immunohistochemistry) was increased in the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MnPO), subfornical organ (SFO), and supraoptic nucleus (SON) after water deprivation. After rehydration with water but before consumption of 1.8% NaCl, Fos expression in the SON disappeared and was partially reduced in the OVLT and MnPO. However, Fos expression did not change in the SFO. Water deprivation also 1) increased plasma renin activity (PRA), osmolality, and plasma Na+; 2) decreased blood volume; and 3) reduced total body Na+; but 4) did not alter arterial blood pressure. Rehydration with water alone caused only plasma osmolality and plasma Na+concentration to revert to euhydrated levels. The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water.

Details

Title: Subtitle: Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genes
Creators: Laurival A De Luca - Department of Physiology and Pathology, School of Dentistry, Paulista State University, São Paulo 14801-903, Araraquara, Brazil
Zhice Xu - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and
Guus H. M Schoorlemmer - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and
Robert L Thunhorst - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and
Terry G Beltz - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and
José V Menani - Department of Physiology and Pathology, School of Dentistry, Paulista State University, São Paulo 14801-903, Araraquara, Brazil
Alan Kim Johnson - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.282(2), pp.R552-R559
DOI: 10.1152/ajpregu.00295.2000
PMID: 11792666
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Language: English
Date published: 02/01/2002
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213277202771

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