Journal article
Weekly high-dose calcitriol and docetaxel in patients with metastatic hormone-refractory prostate cancer previously exposed to docetaxel
BJU international, Vol.100(4), pp.775-779
10/2007
DOI: 10.1111/j.1464-410X.2007.07019.x
PMID: 17535276
Abstract
OBJECTIVE
To evaluate the activity and tolerability of weekly high-dose calcitriol and docetaxel in patients with metastatic hormone-refractory prostate cancer (HRPC) previously exposed to docetaxel, as patients who progress after docetaxel treatment might be considered for second-line chemotherapy, but with no standard salvage therapy available we hypothesised that high-dose calcitriol might restore sensitivity to chemotherapy.
PATIENTS AND METHODS
The study comprised 26 patients who had progressed after first-line treatment with docetaxel-based chemotherapy had failed. Treatment cycles consisted of calcitriol (32 µg orally as 0.5 µg tablets) on day 1 and docetaxel (30 mg/m2 intravenous) on day 2, administered for six consecutive weeks followed by a 2-week rest interval for a maximum of 24 cycles.
RESULTS
There was a response in prostate-specific antigen (PSA) level in eight patients (31%); seven (27%) had a stable PSA level for ≥ 12 weeks. The median time to PSA progression was 4.2 months and the median survival was 9.3 months. The regimen was generally well tolerated; there was grade 2 hypercalcaemia, probably related to calcitriol, in one patient after six treatment cycles.
CONCLUSION
Weekly high-dose calcitriol and docetaxel seems to be an effective and well-tolerated treatment option for patients with metastatic HRPC previously exposed to docetaxel-based chemotherapy.
Details
- Title: Subtitle
- Weekly high-dose calcitriol and docetaxel in patients with metastatic hormone-refractory prostate cancer previously exposed to docetaxel
- Creators
- Roberto Petrioli - University of SienaAlessandra Pascucci - University of SienaEdoardo Francini - University of SienaStefania Marsili - University of SienaAngela Sciandivasci - University of SienaGiovanni De Rubertis - University of SienaGabriele Barbanti - University of SienaAntonio Manganelli - University of SienaFrancesco Salvestrini - University of SienaGuido Francini - University of Siena
- Resource Type
- Journal article
- Publication Details
- BJU international, Vol.100(4), pp.775-779
- DOI
- 10.1111/j.1464-410X.2007.07019.x
- PMID
- 17535276
- ISSN
- 1464-4096
- eISSN
- 1464-410X
- Number of pages
- 5
- Language
- English
- Date published
- 10/2007
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221247402771
Metrics
1 Record Views