Journal article
Weight gain associated with the -759C/T polymorphism of the 5HT2C receptor and olanzapine
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.134B(1), pp.76-78
04/05/2005
DOI: 10.1002/ajmg.b.20169
PMID: 15666332
Abstract
Weight gain from atypical antipsychotic use has become a significant problem. Recent reports have liked the -759 polymorphism of the 5HT2C receptor and obesity as well as weight gain from chlorpromazine, risperidone, and clozapine.
To determine associations between weight gain during olanzapine treatment and the -759C/T polymorphism of the 5HT2C receptor gene.
This study included 42 acutely ill patients with schizophrenia (DSM-IV). Weekly assessments included Brief Psychiatric Rating Scale (BPRS), Scale for Assessment of Negative Symptoms (SANS), and weight measurements. Olanzapine was titrated to a fixed dose (7.5-20 mg/day) for 2-6 weeks. A 24 hr plasma level was obtained at the endpoint visit. Genomic DNA was isolated from a whole blood sample and analyzed for the -759C/T polymorphism of the 5HT2C receptor.
A chi-square analysis was conducted comparing the distribution of T and C alleles in subjects grouped as gaining more or less than 5, 7, and 10% of their baseline weight during treatment with olanzapine. A threshold of 10% was found to be significant. The distribution of T alleles was higher in subjects not gaining 10% of more of their body weight compared who did gain significant weight (11/27 (40.7%) vs. 0/15 (100%), chi2 = 11.805, P = 0.0035).
Subjects with a T allele of the 5HT2C receptor -759C/T polymorphism may have a lower incidence of weight gain from olanzapine over a 6 week period compared to those with the C allele. These results need to be replicated.
Details
- Title: Subtitle
- Weight gain associated with the -759C/T polymorphism of the 5HT2C receptor and olanzapine
- Creators
- Vicki L Ellingrod - University of Iowa, College of Pharmacy, Iowa, USA. vicki-ellingrod@uiowa.eduPaul J PerryJohn C RingoldBrian C LundKristy Bever-StilleFrank FlemingTimothy L HolmanDel Miller
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.134B(1), pp.76-78
- Publisher
- United States
- DOI
- 10.1002/ajmg.b.20169
- PMID
- 15666332
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Language
- English
- Date published
- 04/05/2005
- Academic Unit
- Pharmacy; Psychiatry; Epidemiology
- Record Identifier
- 9984003945202771
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