Journal article
What Every Neuropathologist Needs to Know: The Muscle Biopsy
Journal of neuropathology and experimental neurology, Vol.79(7), pp.719-733
07/01/2020
DOI: 10.1093/jnen/nlaa046
PMID: 32529201
Abstract
Abstract Competence in muscle biopsy evaluation is a core component of neuropathology practice. The practicing neuropathologist should be able to prepare frozen sections of muscle biopsies with minimal artifacts and identify key histopathologic features of neuromuscular disease in hematoxylin and eosin-stained sections as well as implement and interpret a basic panel of additional histochemical, enzyme histochemical, and immunohistochemical stains. Important to everyday practice is a working knowledge of normal muscle histology at different ages, muscle motor units, pitfalls of myotendinous junctions, nonpathologic variations encountered at traditional and nontraditional muscle sites, the pathophysiology of myonecrosis and regeneration, and approaches to distinguish muscular dystrophies from inflammatory myopathies and other necrotizing myopathies. Here, we provide a brief overview of what every neuropathologist needs to know concerning the muscle biopsy.
Details
- Title: Subtitle
- What Every Neuropathologist Needs to Know: The Muscle Biopsy
- Creators
- James S Nix - Johns Hopkins University School of MedicineSteven A Moore - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neuropathology and experimental neurology, Vol.79(7), pp.719-733
- DOI
- 10.1093/jnen/nlaa046
- PMID
- 32529201
- NLM abbreviation
- J Neuropathol Exp Neurol
- ISSN
- 0022-3069
- eISSN
- 1554-6578
- Grant note
- name: NIH, award: U54, NS053672; name: Iowa Wellstone Muscular Dystrophy Cooperative Research Center
- Language
- English
- Date published
- 07/01/2020
- Academic Unit
- Pathology
- Record Identifier
- 9984186547802771
Metrics
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