Journal article
What can we learn about age-related macular degeneration from other retinal diseases?
Molecular vision, Vol.5, p.30
11/03/1999
PMID: 10562654
Abstract
Age-related macular degeneration (AMD) is increasingly recognized as a complex genetic disorder in which one or more genes contribute to an individual's susceptibility for developing the condition. Twin and family studies as well as population-based genetic epidemiologic methods have convincingly demonstrated the importance of genetics in AMD, though the extent of heritability, the number of genes involved, and the phenotypic and genetic heterogeneity of the condition remain unresolved. The extent to which other hereditary macular dystrophies such as Stargardts disease, familial radial drusen (malattia leventinese), Best's disease, and peripherin/RDS-related dystrophy are related to AMD remains unclear. Alzheimer's disease, another late onset, heterogeneous degenerative disorder of the central nervous system, offers a valuable model for identifying the issues that confront AMD genetics.
Details
- Title: Subtitle
- What can we learn about age-related macular degeneration from other retinal diseases?
- Creators
- D J Zack - Departments of Ophthalmology, Molecular Biology and Genetics, and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. dzack@bs.jhmi.eduM DeanR S MoldayJ NathansT M RedmondE M StoneA SwaroopD ValleB H Weber
- Resource Type
- Journal article
- Publication Details
- Molecular vision, Vol.5, p.30
- PMID
- 10562654
- NLM abbreviation
- Mol Vis
- ISSN
- 1090-0535
- eISSN
- 1090-0535
- Publisher
- United States
- Language
- English
- Date published
- 11/03/1999
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980019602771
Metrics
30 Record Views