Journal article
What controls the length of noncoding DNA?
Current Opinion in Genetics & Development, Vol.11(6), pp.652-659
2001
DOI: 10.1016/S0959-437X(00)00249-5
PMID: 11682309
Abstract
Several recent studies of genome evolution indicate that the rate of DNA loss exceeds that of DNA gain, leading to an underlying mutational pressure towards collapsing the length of noncoding DNA. That such a collapse is not observed suggests opposing mechanisms favoring longer noncoding regions. The presence of transposable elements alone also does not explain observed features of noncoding DNA. At present, a multidisciplinary approach — using population genetics techniques, large-scale genomic analyses, and
in silico evolution — is beginning to provide new and valuable insights into the forces that shape the length of noncoding DNA and, ultimately, genome size. Recombination, in a broad sense, might be the missing key parameter for understanding the observed variation in length of noncoding DNA in eukaryotes.
Details
- Title: Subtitle
- What controls the length of noncoding DNA?
- Creators
- Josep M Comeron - Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
- Resource Type
- Journal article
- Publication Details
- Current Opinion in Genetics & Development, Vol.11(6), pp.652-659
- DOI
- 10.1016/S0959-437X(00)00249-5
- PMID
- 11682309
- NLM abbreviation
- Curr Opin Genet Dev
- ISSN
- 0959-437X
- eISSN
- 1879-0380
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2001
- Academic Unit
- Biology
- Record Identifier
- 9983992088802771
Metrics
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