Journal article
What is the appropriate intravenous dose of vitamin E for very-low-birth-weight infants?
Journal of perinatology, Vol.24(4), pp.205-207
04/2004
DOI: 10.1038/sj.jp.7211078
PMID: 15067295
Abstract
The Committee on Fetus and Newborn of the American Academy of Pediatrics (AAP) has endorsed 1 to 2 mg/dl as the normal range of serum tocopherol level. Our Cochrane review has shown that vitamin E supplementation resulting in levels >3.5 mg/dl, but not < or =3.5 mg/dl, significantly reduces the risk for severe retinopathy among very-low-birth-weight (VLBW) infants examined but increases the risks of sepsis and of necrotizing enterocolitis among infants treated for >1 week. As a fixed daily intravenous dose of vitamin E results in an inverse relationship between serum level and birth weight and is a risk for both low and high serum tocopherol levels, a dose adjusted for current weight appears more judicious than a fixed dose per day. Based on currently available data the AAP and the American Society for Clinical Nutrition currently recommend a routine intake of 2 ml/kg/day of MVI Pediatric (2.8 IU/kg/day) in VLBW infants (maximum of 5 ml/day or 7 IU/day).
Details
- Title: Subtitle
- What is the appropriate intravenous dose of vitamin E for very-low-birth-weight infants?
- Creators
- Luc P Brion - Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY 10461-2373, USAEdward F BellTalkad S RaghuveerLamia Soghier
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.24(4), pp.205-207
- DOI
- 10.1038/sj.jp.7211078
- PMID
- 15067295
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Language
- English
- Date published
- 04/2004
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093603302771
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