White clot syndrome associated with renal failure

D L Somers; C Sotolongo; J A Bertolatus

doi:10.1681/ASN.V42137

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White clot syndrome associated with renal failure

Journal article

Open access

White clot syndrome associated with renal failure

D L Somers, C Sotolongo and J A Bertolatus

Journal of the American Society of Nephrology, Vol.4(2), pp.137-141

08/1993

DOI: 10.1681/ASN.V42137

PMID: 8400075

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Abstract

In a minority of patients, heparin administration is associated with thrombocytopenia and this thrombocytopenia may be associated with thromboembolic events. Heparin-associated thromboembolism is described as heparin-associated thrombocytopenia and thrombosis or white clot syndrome. White clot syndrome is caused by antibodies to a heparin-platelet membrane complex. The diagnosis carries a high mortality and morbidity from limb thromboembolism. Treatment includes discontinuation of heparin, use of alternate anticoagulants, and aggressive treatment of thromboses. A case in which acute renal failure occurred in the setting of heparin treatment and thrombocytopenia is described, and evidence that renal failure was a result of white clot syndrome is provided.

Heparin - metabolism

Thrombosis - chemically induced

Thrombosis - complications

Humans

Middle Aged

Carcinoma, Squamous Cell - surgery

Sepsis - complications

Disseminated Intravascular Coagulation - complications

Heparin - adverse effects

Thrombocytopenia - complications

Platelet Membrane Glycoproteins - metabolism

Fatal Outcome

Female

Renal Veins

Postoperative Complications - drug therapy

Acute Kidney Injury - etiology

Pulmonary Embolism - complications

Thrombocytopenia - immunology

Thrombosis - immunology

Thrombocytopenia - chemically induced

Antigens, Human Platelet - immunology

Syndrome

Platelet Aggregation

Heparin - immunology

Carcinoma, Squamous Cell - complications

Protein Binding

Head and Neck Neoplasms - complications

Pulmonary Embolism - drug therapy

Head and Neck Neoplasms - surgery

Details

Title: Subtitle: White clot syndrome associated with renal failure
Creators: D L Somers - Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City 52242
C Sotolongo
J A Bertolatus
Resource Type: Journal article
Publication Details: Journal of the American Society of Nephrology, Vol.4(2), pp.137-141
DOI: 10.1681/ASN.V42137
PMID: 8400075
NLM abbreviation: J Am Soc Nephrol
ISSN: 1046-6673
eISSN: 1533-3450
Language: English
Date published: 08/1993
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094484002771

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6 Times Cited - Web of Science