White matter correlates of episodic memory encoding and retrieval in schizophrenia

Amity E Green; Rodney J Croft; Jerome J Maller; Paul B Fitzgerald

doi:10.1016/j.pscychresns.2016.07.002

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White matter correlates of episodic memory encoding and retrieval in schizophrenia

Journal article

Peer reviewed

White matter correlates of episodic memory encoding and retrieval in schizophrenia

Amity E Green, Rodney J Croft, Jerome J Maller and Paul B Fitzgerald

Psychiatry research. Neuroimaging, Vol.254, pp.188-198

08/30/2016

DOI: 10.1016/j.pscychresns.2016.07.002

PMID: 27479923

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Abstract

Episodic memory (EM) impairments in schizophrenia (SZ) are predictive of functional outcome and are a potential endophenotype of the disorder. The current study investigated the neuroanatomical correlates of EM encoding and retrieval in SZ with structural magnetic resonance and diffusion tensor imaging (DTI) measures in 22 patients with SZ and 22 age- and gender-matched healthy controls. Tract-based Spatial Statistics (TBSS) was used to investigate microstructural alterations in white matter (WM), while FreeSurfer surface-based analysis was used to determine abnormalities in grey matter (GM) and WM volumetrics and cortical thickness. Compared to controls, patients demonstrated GM deficits in temporal and parietal regions and lower fractional anisotropy (FA) of WM in diffuse brain regions. Patients also demonstrated reduced functioning in both encoding and retention of auditory-verbal EM. Among patients but not controls, EM encoding correlated with WM volume in the orbitofrontal cortex and increased radial diffusivity in the fornix, whereas EM retrieval correlated with WM volume in posterior parietal cortex. These findings suggest a differential role for frontal and parietal WM in EM encoding and retrieval processes, while myelin integrity of the fornix may play a specific role in mediating EM encoding processes in SZ.

Adult

Anisotropy

Brain - diagnostic imaging

Brain - pathology

Brain Mapping

Case-Control Studies

Diffusion Tensor Imaging

Female

Fornix, Brain - diagnostic imaging

Fornix, Brain - pathology

Gray Matter - diagnostic imaging

Gray Matter - pathology

Humans

Male

Memory Disorders - diagnostic imaging

Memory Disorders - pathology

Memory Disorders - physiopathology

Memory Disorders - psychology

Memory, Episodic

Middle Aged

Myelin Sheath

Parietal Lobe - diagnostic imaging

Parietal Lobe - pathology

Prefrontal Cortex - diagnostic imaging

Prefrontal Cortex - pathology

Psychotic Disorders - diagnostic imaging

Psychotic Disorders - pathology

Psychotic Disorders - physiopathology

Psychotic Disorders - psychology

Schizophrenia - diagnostic imaging

Schizophrenia - pathology

Schizophrenia - physiopathology

Schizophrenic Psychology

Temporal Lobe - diagnostic imaging

Temporal Lobe - pathology

White Matter - diagnostic imaging

White Matter - pathology

Details

Title: Subtitle: White matter correlates of episodic memory encoding and retrieval in schizophrenia
Creators: Amity E Green - Monash Alfred Psychiatry Research centre
Rodney J Croft - Illawarra Health and Medical Research Institute
Jerome J Maller - Monash Alfred Psychiatry Research centre
Paul B Fitzgerald - Monash Alfred Psychiatry Research centre
Resource Type: Journal article
Publication Details: Psychiatry research. Neuroimaging, Vol.254, pp.188-198
DOI: 10.1016/j.pscychresns.2016.07.002
PMID: 27479923
NLM abbreviation: Psychiatry Res Neuroimaging
ISSN: 0925-4927
eISSN: 1872-7506
Language: English
Date published: 08/30/2016
Academic Unit: Radiology
Record Identifier: 9984848420202771

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