White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control

Jiefeng Jiang; Joel Bruss; Woo-Tek Lee; Daniel Tranel; Aaron D Boes

doi:10.1038/s41467-023-37330-1

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White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control

Journal article

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White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control

Jiefeng Jiang, Joel Bruss, Woo-Tek Lee, Daniel Tranel and Aaron D Boes

Nature communications, Vol.14(1), 1740

03/29/2023

DOI: 10.1038/s41467-023-37330-1

PMCID: PMC10060223

PMID: 36990985

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Abstract

Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the white matter, little is known about the anatomy of white matter tracts that coordinate the distributed neural computations that support cognitive control. Here, we leverage a large sample of human patients with focal brain lesions (n = 643) and investigate how lesion location and connectivity profiles account for variance in cognitive control performance. We find that lesions in white matter connecting left frontoparietal regions of the multiple demand network reliably predict deficits in cognitive control performance. These findings advance our understanding of the white matter correlates of cognitive control and provide an approach for incorporating network disconnection to predict deficits following lesions.

Magnetic Resonance Imaging

Cognition

Humans

White Matter - diagnostic imaging

White Matter - pathology

Details

Title: Subtitle: White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
Creators: Jiefeng Jiang - University of Iowa
Joel Bruss - University of Iowa
Woo-Tek Lee - University of Iowa
Daniel Tranel - University of Iowa
Aaron D Boes - University of Iowa
Resource Type: Journal article
Publication Details: Nature communications, Vol.14(1), 1740
DOI: 10.1038/s41467-023-37330-1
PMID: 36990985
PMCID: PMC10060223
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Grant note: R01MH131559 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01 MH131559 / NIMH NIH HHS R01NS114405 / U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
Language: English
Date published: 03/29/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984381025102771

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