White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study

Katja Vogel; Inge Timmers; Vinod Kumar; Thomas Nickl-Jockschat; Matteo Bastiani; Alard Roebroek; Beate Herpertz-Dahlmann; Kerstin Konrad; Rainer Goebel; Jochen Seitz

doi:10.1016/j.nicl.2016.04.002

Back

White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study

Journal article

Open access

Peer reviewed

White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study

Katja Vogel, Inge Timmers, Vinod Kumar, Thomas Nickl-Jockschat, Matteo Bastiani, Alard Roebroek, Beate Herpertz-Dahlmann, Kerstin Konrad, Rainer Goebel and Jochen Seitz

NeuroImage clinical, Vol.11(C), pp.614-621

2016

DOI: 10.1016/j.nicl.2016.04.002

PMID: 27182488

Files and links (1)

url

https://doi.org/10.1016/j.nicl.2016.04.002View

Published (Version of record) Open Access

Abstract

Anorexia nervosa (AN) often begins in adolescence, however, the understanding of the underlying pathophysiology at this developmentally important age is scarce, impeding early interventions. We used diffusion tensor imaging (DTI) to investigate microstructural white matter (WM) brain changes including an experimental longitudinal follow-up. We acquired whole brain diffusion-weighted brain scans of 22 adolescent female hospitalized patients with AN at admission and nine patients longitudinally at discharge after weight rehabilitation. Patients (10-18 years) were compared to 21 typically developing controls (TD). Tract-based spatial statistics (TBSS) were applied to compare fractional anisotropy (FA) across groups and time points. Associations between average FA values of the global WM skeleton and weight as well as illness duration parameters were analyzed by multiple linear regression. We observed increased FA in bilateral frontal, parietal and temporal areas in AN patients at admission compared to TD. Higher FA of the global WM skeleton at admission was associated with faster weight loss prior to admission. Exploratory longitudinal analysis showed this FA increase to be partially normalized after weight rehabilitation. Our findings reveal a markedly different pattern of WM microstructural changes in adolescent AN compared to most previous results in adult AN. This could signify a different susceptibility and reaction to semi-starvation in the still developing brain of adolescents or a time-dependent pathomechanism differing with extend of chronicity. Higher FA at admission in adolescents with AN could point to WM fibers being packed together more closely.

Brain - diagnostic imaging

Humans

Anorexia Nervosa - pathology

Diffusion Tensor Imaging

Psychiatric Status Rating Scales

White Matter - diagnostic imaging

Analysis of Variance

Image Processing, Computer-Assisted

Anisotropy

Adolescent

Brain - pathology

Brain Mapping

Female

Retrospective Studies

Child

Longitudinal Studies

Details

Title: Subtitle: White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study
Creators: Katja Vogel - Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen University, Neuenhofer Weg 21, 52074 Aachen, Germany
Inge Timmers - Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Vinod Kumar - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany; JARA-Translational Brain Medicine (The Jülich Aachen Research Alliance), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany
Thomas Nickl-Jockschat - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany; JARA-Translational Brain Medicine (The Jülich Aachen Research Alliance), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany
Matteo Bastiani - Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands; Oxford Centre for Functional MRI of the Brain, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Alard Roebroek - Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Beate Herpertz-Dahlmann - Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen University, Neuenhofer Weg 21, 52074 Aachen, Germany
Kerstin Konrad - Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen University, Neuenhofer Weg 21, 52074 Aachen, Germany
Rainer Goebel - Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Jochen Seitz - Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen University, Neuenhofer Weg 21, 52074 Aachen, Germany; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. Electronic address: jseitz@ukaachen.de
Resource Type: Journal article
Publication Details: NeuroImage clinical, Vol.11(C), pp.614-621
DOI: 10.1016/j.nicl.2016.04.002
PMID: 27182488
NLM abbreviation: Neuroimage Clin
ISSN: 2213-1582
eISSN: 2213-1582
Publisher: Netherlands
Language: English
Date published: 2016
Academic Unit: Psychiatry; Neuroscience and Pharmacology
Record Identifier: 9984003411602771

Metrics

15 Record Views

42 Times Cited - Web of Science

See more details