Journal article
White matter predicts functional connectivity in premanifest Huntington's disease
Annals of clinical and translational neurology, Vol.4(2), pp.106-118
02/2017
DOI: 10.1002/acn3.384
PMCID: PMC5288460
PMID: 28168210
Abstract
Objectives: The distribution of pathology in neurodegenerative disease can be predicted by the organizational characteristics of white matter in healthy brains. However, we have very little evidence for the impact these pathological changes have on brain function. Understanding any such link between structure and function is critical for understanding how underlying brain pathology influences the progressive behavioral changes associated with neurodegeneration. Here, we demonstrate such a link between structure and function in individuals with premanifest Huntington's. Methods: Using diffusion tractography and resting state functional magnetic resonance imaging to characterize white matter organization and functional connectivity, we investigate whether characteristic patterns of white matter organization in the healthy human brain shape the changes in functional coupling between brain regions in premanifest Hunting-ton's disease. Results: We find changes in functional connectivity in premani-fest Huntington's disease that link directly to underlying patterns of white matter organization in healthy brains. Specifically, brain areas with strong structural connectivity show decreases in functional connectivity in premanifest Huntington's disease relative to controls, while regions with weak structural connectivity show increases in functional connectivity. Furthermore, we identify a pattern of dissociation in the strongest functional connections between anterior and posterior brain regions such that anterior functional connectivity increases in strength in premanifest Huntington's disease, while posterior functional connectivity decreases. Interpretation: Our findings demonstrate that organizational principles of white matter underlie changes in functional connec-tivity in premanifest Huntington's disease. Furthermore, we demonstrate functional antero–posterior dissociation that is in keeping with the caudo–rostral gradient of striatal pathology in HD.
Details
- Title: Subtitle
- White matter predicts functional connectivity in premanifest Huntington's disease
- Creators
- Peter Mccolgan - UCL, Institute of NeurologySarah Gregory - Wellcome Department of Imaging NeuroscienceAdeel Razi - NED University of Engineering & TechnologyKiran K Seunarine - Institute of Child LondonFatma Gargouri - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine InstituteAlexandra Durr - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine InstituteRaymund A.C Roos - Leiden University Medical Center (LUMC)Blair R Leavitt - University of British ColumbiaRachael I Scahill - UCL, Institute of NeurologyChris A Clark - Institute of Child LondonSarah J Tabrizi - National Hospital for Neurology and Neurosurgery- LondonGeraint Rees - Wellcome Department of Imaging NeuroscienceTrack On-HD Investigators
- Contributors
- Hans J Johnson (Contributor) - University of Iowa, Electrical and Computer Engineering
- Resource Type
- Journal article
- Publication Details
- Annals of clinical and translational neurology, Vol.4(2), pp.106-118
- DOI
- 10.1002/acn3.384
- PMID
- 28168210
- PMCID
- PMC5288460
- NLM abbreviation
- Ann Clin Transl Neurol
- ISSN
- 2328-9503
- eISSN
- 2328-9503
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/100004440, name: Wellcome Trust, award: 091593/Z/10/Z, 515103; DOI: 10.13039/501100000272, name: National Institute for Health Research; DOI: 10.13039/100005725, name: CHDI Foundation
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
- Record Identifier
- 9984221628802771
Metrics
13 Record Views