Journal article
White paper on antimicrobial stewardship in solid organ transplant recipients
American journal of transplantation, Vol.22(1), pp.96-112
01/01/2022
DOI: 10.1111/ajt.16743
PMCID: PMC9695237
PMID: 34212491
Abstract
Antimicrobial stewardship programs (ASPs) have made immense strides in optimizing antibiotic, antifungal, and antiviral use in clinical settings. However, although ASPs are required institutionally by regulatory agencies in the United States and Canada, they are not mandated for transplant centers or programs specifically. Despite the fact that solid organ transplant recipients in particular are at increased risk of infections from multidrug-resistant organisms, due to host and donor factors and immunosuppressive therapy, there currently are little rigorous data regarding stewardship practices in solid organ transplant populations, and thus, no transplant-specific requirements currently exist. Further complicating matters, transplant patients have a wide range of variability regarding their susceptibility to infection, as factors such as surgery of transplant, intensity of immunosuppression, and presence of drains or catheters in situ may modify the risk of infection. As such, it is not feasible to have a "one-size-fits-all" style of stewardship for this patient population. The objective of this white paper is to identify opportunities, risk factors, and ASP strategies that should be assessed with solid organ transplant recipients to optimize antimicrobial use, while producing an overall improvement in patient outcomes. We hope it may serve as a springboard for development of future guidance and identification of research opportunities.
Details
- Title: Subtitle
- White paper on antimicrobial stewardship in solid organ transplant recipients
- Creators
- Miranda So - University of TorontoJonathan Hand - Ochsner Medical CenterGraeme Forrest - Rush University Medical CenterStephanie M. Pouch - Emory UniversityHelen Te - University of ChicagoMonica Ardura - Nationwide Children's HospitalRachel M. Bartash - Albert Einstein College of MedicineDarshana M. Dadhania - NewYork–Presbyterian HospitalJeffrey Edelman - University of Washington Medical CenterDilek Ince - Roy J. and Lucille A. Carver College of MedicineMargaret R. Jorgenson - UW Health University HospitalSarah Kabbani - Centers for Disease Control and PreventionErika D. Lease - University of WashingtonDeborah Levine - The University of Texas at San Antonio Health Science CenterLinda Ohler - NYU Langone HealthGopi Patel - Icahn School of Medicine at Mount SinaiJennifer Pisano - University of ChicagoMichael L. Spinner - Cleveland ClinicLilian Abbo - Miami Transplant InstituteElizabeth C. Verna - Columbia University Irving Medical CenterShahid Husain - University Health Network
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.22(1), pp.96-112
- DOI
- 10.1111/ajt.16743
- PMID
- 34212491
- PMCID
- PMC9695237
- NLM abbreviation
- Am J Transplant
- ISSN
- 1600-6135
- eISSN
- 1600-6143
- Publisher
- Wiley
- Number of pages
- 17
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984359919102771
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