Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis

Renxin Chu; Shahamat Tauhid; Bonnie I Glanz; Brian C Healy; Gloria Kim; Vinit V Oommen; Fariha Khalid; Mohit Neema; Rohit Bakshi

doi:10.1111/jon.12271

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Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis

Journal article

Open access

Peer reviewed

Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis

Renxin Chu, Shahamat Tauhid, Bonnie I Glanz, Brian C Healy, Gloria Kim, Vinit V Oommen, Fariha Khalid, Mohit Neema and Rohit Bakshi

Journal of neuroimaging, Vol.26(1), pp.62-67

01/2016

DOI: 10.1111/jon.12271

PMCID: PMC4755143

PMID: 26118637

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Abstract

Whole brain atrophy is a putative outcome measure in monitoring relapsing-remitting multiple sclerosis (RRMS). With the ongoing MRI transformation from 1.5T to 3T, there is an unmet need to calibrate this change. We evaluated brain parenchymal volumes (BPVs) from 1.5T versus 3T in MS and normal controls (NC). We studied MS [n = 26, age (mean, range) 43 (21-55), 22 (85%) RRMS, Expanded Disability Status Scale (EDSS) 1.98 (0-6.5), timed 25 foot walk (T25FW) 5.95 (3.2-33.0 seconds)] and NC [n = 9, age 45 (31-53)]. Subjects underwent 1.5T (Phillips) and 3T (GE) 3-dimensional T1-weighted scans to derive normalized BPV from an automated SIENAX pipeline. Neuropsychological testing was according to consensus panel recommendations. BPV-1.5T was higher than BPV-3T [mean (95% CI) + 45.7 mL (+35.3, +56.1), P < .00001], most likely due to improved tissue-CSF contrast at 3T. BPV-3T showed a larger volume decrease and larger effect size in detecting brain atrophy in MS versus NC [-74.5 mL (-126.5, -22.5), P = .006, d = .92] when compared to BPV-1.5T [-51.3.1 mL (-99.8, -2.8), P = .04, d = .67]. Correlations between BPV-1.5T and EDSS (r = -.43, P = .027) and BPV-3T and EDSS (r = -.49, P = .011) and between BPV-1.5T and T25FW (r = -.46, P = .018) and BPV-3T and T25FW (r = -.56, P = .003) slightly favored 3T. BPV-cognition correlations were significant (P < .05) for 6 of 11 subscales to a similar degree at 1.5T (r range = .44-.58) and 3T (r range = .43-.53). Field strength may impact whole brain volume measurements in patients with MS though the differences are not too divergent between 1.5T and 3T.

Adult

Atrophy - diagnostic imaging

Atrophy - pathology

Brain - diagnostic imaging

Brain - pathology

Disability Evaluation

Female

Healthy Volunteers

Humans

Magnetic Resonance Imaging - methods

Male

Middle Aged

Multiple Sclerosis - diagnostic imaging

Multiple Sclerosis - pathology

Neuroimaging - methods

Organ Size

Prospective Studies

Young Adult

Details

Title: Subtitle: Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis
Creators: Renxin Chu - Brigham and Women's Hospital
Shahamat Tauhid - Brigham and Women's Hospital
Bonnie I Glanz - Brigham and Women's Hospital
Brian C Healy - Brigham and Women's Hospital
Gloria Kim - Brigham and Women's Hospital
Vinit V Oommen - Brigham and Women's Hospital
Fariha Khalid - Brigham and Women's Hospital
Mohit Neema - Brigham and Women's Hospital
Rohit Bakshi - Brigham and Women's Hospital
Resource Type: Journal article
Publication Details: Journal of neuroimaging, Vol.26(1), pp.62-67
DOI: 10.1111/jon.12271
PMID: 26118637
PMCID: PMC4755143
ISSN: 1051-2284
eISSN: 1552-6569
Language: English
Date published: 01/2016
Academic Unit: Psychiatry
Record Identifier: 9984627339202771

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