Journal article
Whole-Genome Analysis of Dorsal-Ventral Patterning in the Drosophila Embryo
Cell, Vol.111(5), pp.687-701
2002
DOI: 10.1016/S0092-8674(02)01087-5
PMID: 12464180
Abstract
The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early
Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tissue-specific form of the NF-Y transcription complex is essential for the activation of gene expression in the mesoderm. Tissue-specific enhancers were identified for new Dorsal target genes, and bioinformatics methods identified conserved
cis-regulatory elements for coordinately regulated genes that respond to similar thresholds of the Dorsal gradient. The new Dorsal target genes and enhancers represent one of the most extensive gene networks known for any developmental process.
Details
- Title: Subtitle
- Whole-Genome Analysis of Dorsal-Ventral Patterning in the Drosophila Embryo
- Creators
- Angelike Stathopoulos - Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, Berkeley, CA 94720 USAMadeleine Van Drenth - Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, Berkeley, CA 94720 USAAlbert Erives - Auilix Biopharma, Inc., 950 Gilman Street, Berkeley, CA 94710 USAMichele Markstein - Committee on Developmental Biology, University of Chicago, Cummings Life Sciences Center, 755, 920 East 58th Street, Chicago, IL 60637 USAMichael Levine - Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, Berkeley, CA 94720 USA
- Resource Type
- Journal article
- Publication Details
- Cell, Vol.111(5), pp.687-701
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0092-8674(02)01087-5
- PMID
- 12464180
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 2002
- Academic Unit
- Biology
- Record Identifier
- 9984217530402771
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