Whole body heat exposure modulates acute glucose metabolism

Amy L Kimball; Patrick M McCue; Michael A Petrie; Richard K Shields

doi:10.1080/02656736.2018.1516303

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Whole body heat exposure modulates acute glucose metabolism

Journal article

Open access

Peer reviewed

Whole body heat exposure modulates acute glucose metabolism

Amy L Kimball, Patrick M McCue, Michael A Petrie and Richard K Shields

International journal of hyperthermia, Vol.35(1), pp.644-651

12/31/2018

DOI: 10.1080/02656736.2018.1516303

PMID: 30303421

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Abstract

Aim: Exercise modulates glucose tolerance and homeostasis in both healthy and diabetic individuals. Heat stress is a fundamental element of exercise. The acute glycemic response and alterations in glucose clearance following whole body passive heat stress in the absence of muscle activity has yet to be examined in humans. Knowledge of this relationship may prove useful, particularly in populations with compromised glucoregulation from reduced activity. Purpose: To determine insulin/glucose levels before and after an acute bout of heat stress in healthy, lean individuals and examine the effects of whole body heat stress (WBHS) and exercise on acute glucose tolerance in an expanded cohort. Methods: Ten subjects (24.1 ± 0.7 years) participated in a randomized control/WBHS session (up to 30 minutes at 73 °C) with fasting glucose (FG) and insulin drawn at baseline, immediately after and 30 minutes post heat stress. In the follow-up experiment, 20 anthropometrically diverse subjects (24.6 ± 2.1 years) underwent an oral glucose tolerance test (OGTT) under the conditions above. Results: FG levels rose 10% immediately following heat stress (8.6 (±5.6) mg/dl, p < .01) and returned to near baseline levels 30 minutes following WBHS. Insulin release showed its greatest increase at 30 minutes post WBHS (2.7 ± 3.5) uU/ml p < .05). WBHS resulted in a decrease in glucose uptake [AUC increased 8.2% (1430.6 ± 1957.03) mg/dl (p = .005)], particularly in nonlean individuals. Conclusion: WBHS modulates physiologic markers of metabolism. An acute bout of WBHS increases glucose and insulin levels in healthy individual and decreases glucose uptake in response to a glucose challenge, particularly those who are non-lean.

glucose

insulin

Whole body heat stress

glucose metabolism

Details

Title: Subtitle: Whole body heat exposure modulates acute glucose metabolism
Creators: Amy L Kimball - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa
Patrick M McCue - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa
Michael A Petrie - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa
Richard K Shields - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa
Resource Type: Journal article
Publication Details: International journal of hyperthermia, Vol.35(1), pp.644-651
DOI: 10.1080/02656736.2018.1516303
PMID: 30303421
NLM abbreviation: Int J Hyperthermia
ISSN: 0265-6736
eISSN: 1464-5157
Publisher: Taylor & Francis
Grant note: American Physical Therapy Association
Language: English
Date published: 12/31/2018
Academic Unit: Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science
Record Identifier: 9984047799402771

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