Journal article
Whole-brain 3D MR fingerprinting brain imaging: clinical validation and feasibility to patients with meningioma
Magma (New York, N.Y.), Vol.34(5), pp.697-706
10/01/2021
DOI: 10.1007/s10334-021-00924-1
PMCID: PMC8421277
PMID: 33945050
Abstract
Purpose MR fingerprinting (MRF) is a MR technique that allows assessment of tissue relaxation times. The purpose of this study is to evaluate the clinical application of this technique in patients with meningioma. Materials and methods A whole-brain 3D isotropic 1mm(3) acquisition under a 3.0T field strength was used to obtain MRF T-1 and T-2-based relaxometry values in 4:38 s. The accuracy of values was quantified by scanning a quantitative MR relaxometry phantom. In vivo evaluation was performed by applying the sequence to 20 subjects with 25 meningiomas. Regions of interest included the meningioma, caudate head, centrum semiovale, contralateral white matter and thalamus. For both phantom and subjects, mean values of both T-1 and T-2 estimates were obtained. Statistical significance of differences in mean values between the meningioma and other brain structures was tested using a Friedman's ANOVA test. Results MR fingerprinting phantom data demonstrated a linear relationship between measured and reference relaxometry estimates for both T-1 (r(2) = 0.99) and T-2 (r(2) = 0.97). MRF T-1 relaxation times were longer in meningioma (mean +/- SD 1429 +/- 202 ms) compared to thalamus (mean +/- SD 1054 +/- 58 ms; p = 0.004), centrum semiovale (mean +/- SD 825 +/- 42 ms; p < 0.001) and contralateral white matter (mean +/- SD 799 +/- 40 ms; p < 0.001). MRF T-2 relaxation times were longer for meningioma (mean +/- SD 69 +/- 27 ms) as compared to thalamus (mean +/- SD 27 +/- 3 ms; p < 0.001), caudate head (mean +/- SD 39 +/- 5 ms; p < 0.001) and contralateral white matter (mean +/- SD 35 +/- 4 ms; p < 0.001) Conclusions Phantom measurements indicate that the proposed 3D-MRF sequence relaxometry estimations are valid and reproducible. For in vivo, entire brain coverage was obtained in clinically feasible time and allows quantitative assessment of meningioma in clinical practice.
Details
- Title: Subtitle
- Whole-brain 3D MR fingerprinting brain imaging: clinical validation and feasibility to patients with meningioma
- Creators
- Thomaz R. Mostardeiro - Mayo Clinic in ArizonaAnanya Panda - Mayo Clinic in ArizonaRobert J. Witte - Mayo Clinic in ArizonaNorbert G. Campeau - Mayo Clinic in ArizonaKiaran P. McGee - Mayo Clinic in ArizonaYi Sui - Mayo Clinic in ArizonaAiming Lu - Mayo Clinic in Arizona
- Resource Type
- Journal article
- Publication Details
- Magma (New York, N.Y.), Vol.34(5), pp.697-706
- Publisher
- Springer Nature
- DOI
- 10.1007/s10334-021-00924-1
- PMID
- 33945050
- PMCID
- PMC8421277
- ISSN
- 0968-5243
- eISSN
- 1352-8661
- Number of pages
- 10
- Grant note
- Center of Individualized Medicine at the Mayo Clinic in Rochester, MN
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984697722502771
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