Journal article
Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales
Nature communications, Vol.13(1), pp.1-11
06/01/2022
DOI: 10.1038/s41467-022-30637-5
PMCID: PMC9160272
PMID: 35650193
Abstract
Carbapenemase-producing Enterobacterales cause healthcare-associated infections but modes of transmission are not well understood. Here, the authors find evidence of transmission without direct patient contact, indicating presence of undetected environmental reservoirs, whilst half of the transmission events are likely due to plasmid-mediated transmission.
Details
- Title: Subtitle
- Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales
- Creators
- Kalisvar Marimuthu - National Centre for Infectious DiseasesIndumathi Venkatachalam - Singapore General HospitalVanessa Koh - National Centre for Infectious DiseasesStephan Harbarth - University of GenevaEli Perencevich - University of Iowa, General Internal MedicineBenjamin Pei Zhi Cherng - Yong Loo Lin School of Medicine, National University of Singapore and National University Health SystemRaymond Kok Choon Fong - Changi General HospitalSurinder Kaur Pada - Ng Teng Fong General HospitalSay Tat Ooi - Khoo Teck Puat HospitalNares Smitasin - Yong Loo Lin School of Medicine, National University of Singapore and National University Health SystemKoh Cheng Thoon - KK Women’s and Children’s HospitalPaul Anantharajah Tambyah - National University Hospital and National University Health SystemLi Yang Hsu - Yong Loo Lin School of Medicine, National University of Singapore and National University Health SystemTse Hsien Koh - Singapore General HospitalPartha Pratim De - Tan Tock Seng HospitalThean Yen Tan - Changi General HospitalDouglas Chan - Ng Teng Fong General HospitalRama Narayana Deepak - Khoo Teck Puat HospitalNancy Wen Sim Tee - National University Hospital and National University Health SystemAndrea Kwa - Singapore General HospitalYiying Cai - Singapore General HospitalYik-Ying Teo - Duke UniversityNatascha May Thevasagayam - National Centre for Infectious DiseasesSai Rama Sridatta Prakki - National Centre for Infectious DiseasesWeizhen Xu - National Centre for Infectious DiseasesWei Xin Khong - Tan Tock Seng HospitalDavid Henderson - Clinical Centre, National Institutes of HealthNicole Stoesser - Nuffield Department of Medicine, University of OxfordDavid W. Eyre - University of OxfordDerrick Crook - Nuffield Department of Medicine, University of OxfordMichelle Ang - National Centre for Infectious DiseasesRaymond Tzer Pin Lin - National Centre for Infectious DiseasesAngela Chow - Tan Tock Seng HospitalAlex R. Cook - National University of SingaporeJeanette Teo - National University Hospital and National University Health SystemOon Tek Ng - National Centre for Infectious DiseasesCarbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.13(1), pp.1-11
- DOI
- 10.1038/s41467-022-30637-5
- PMID
- 35650193
- PMCID
- PMC9160272
- NLM abbreviation
- Nat Commun
- eISSN
- 2041-1723
- Publisher
- Nature Portfolio
- Language
- English
- Date published
- 06/01/2022
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984259950102771
Metrics
9 Record Views