Wide-Range Neutron Counting for Yield Prediction of PET Agents in Cyclotron Irradiations

J R Votaw; M R Satter; J J Sunderland; C C Martin; R J Nickles

doi:10.1109/TNS.1987.4337347

Back

Wide-Range Neutron Counting for Yield Prediction of PET Agents in Cyclotron Irradiations

Journal article

Peer reviewed

Wide-Range Neutron Counting for Yield Prediction of PET Agents in Cyclotron Irradiations

J R Votaw, M R Satter, J J Sunderland, C C Martin and R J Nickles

IEEE transactions on nuclear science, Vol.34(1), pp.277-279

02/1987

DOI: 10.1109/TNS.1987.4337347

View Online

Abstract

As PET is moving into the clinical setting, the instrumentation from yesterday's research laboratory is being pressed into routine use in a setting which is intolerant of any unreliability. At the University of Wisconsin, a system of three neutron detectors has been developed to asses the progress of target irradiations in real time. The triad of detectors consists of an NE213 liquid scintillator, a 238U fission detector, and a proton recoil telescope to be able to detect neutron fluence rates over a span of six decades. The signals from these detectors are the inputs to a leaky integrator which calculates the build up of activity in the target. In this way, the cyclotron operator can easily monitor the irradiation and take immediate action, if required, as opposed to finding an empty target at the end of bombardment and falling hopelessly behind schedule. The ability to accurately predict target yields by wide-range neutron counting adds a measure of reliability to radiopharmaceutical production and will facilitate PET becoming a routine clinical tool.

Cyclotrons

Detectors

Instruments

Laboratories

Neutrons

Positron emission tomography

Protons

Real time systems

Signal detection

Telescopes

Details

Title: Subtitle: Wide-Range Neutron Counting for Yield Prediction of PET Agents in Cyclotron Irradiations
Creators: J R Votaw - University of Wisconsin–Madison
M R Satter - Dept. of Medical Physics University of Wisconsin Madison, WI 53706
J J Sunderland - University of Wisconsin–Madison
C C Martin - University of Wisconsin–Madison
R J Nickles - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: IEEE transactions on nuclear science, Vol.34(1), pp.277-279
Publisher: IEEE
DOI: 10.1109/TNS.1987.4337347
ISSN: 0018-9499
eISSN: 1558-1578
Language: English
Date published: 02/1987
Academic Unit: Radiology; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984313081202771

Metrics

8 Record Views