Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup

Emily A Beck; Ana Llopart

doi:10.1038/srep17197

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Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup

Journal article

Open access

Peer reviewed

Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup

Emily A Beck and Ana Llopart

Scientific reports, Vol.5(1), pp.17197-17197

11/25/2015

DOI: 10.1038/srep17197

PMCID: PMC4658640

PMID: 26603658

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Abstract

Rapid evolution of centromeric satellite repeats is thought to cause compensatory amino acid evolution in interacting centromere-associated kinetochore proteins. Cid, a protein that mediates kinetochore/centromere interactions, displays particularly high amino acid turnover. Rapid evolution of both Cid and centromeric satellite repeats led us to hypothesize that the apparent compensatory evolution may extend to interacting partners in the Condensin I complex (i.e., SMC2, SMC4, Cap-H, Cap-D2, and Cap-G) and HP1s. Missense mutations in these proteins often result in improper centromere formation and aberrant chromosome segregation, thus selection for maintained function and coevolution among proteins of the complex is likely strong. Here, we report evidence of rapid evolution and recurrent positive selection in seven centromere-associated proteins in species of the Drosophila melanogaster subgroup, and further postulate that positive selection on these proteins could be a result of centromere drive and compensatory changes, with kinetochore proteins competing for optimal spindle attachment.

Chromosome Segregation

Chromosomal Proteins, Non-Histone - metabolism

Adenosine Triphosphatases - metabolism

Drosophila melanogaster - classification

Drosophila - classification

Centromere - metabolism

Mutation, Missense

Phylogeny

Drosophila Proteins - metabolism

DNA-Binding Proteins - metabolism

Drosophila melanogaster - metabolism

Multiprotein Complexes - metabolism

Animals

Drosophila - metabolism

Evolution, Molecular

Details

Title: Subtitle: Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup
Creators: Emily A Beck - Interdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA, 52242
Ana Llopart - The Department of Biology, The University of Iowa, Iowa City, IA, 52242
Resource Type: Journal article
Publication Details: Scientific reports, Vol.5(1), pp.17197-17197
DOI: 10.1038/srep17197
PMID: 26603658
PMCID: PMC4658640
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: England
Language: English
Date published: 11/25/2015
Academic Unit: Biology
Record Identifier: 9983991997402771

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8 Times Cited - Web of Science