Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution

Joel C Glover; Karen L Elliott; Albert Erives; Victor V Chizhikov; Bernd Fritzsch

doi:10.1016/j.ydbio.2018.02.001

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Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution

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Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution

Joel C Glover, Karen L Elliott, Albert Erives, Victor V Chizhikov and Bernd Fritzsch

Developmental biology, Vol.444 Suppl 1(Suppl 1), pp.S14-S24

12/01/2018

DOI: 10.1016/j.ydbio.2018.02.001

PMCID: PMC6087689

PMID: 29447907

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Abstract

Wilhelm His (1831-1904) provided lasting insights into the development of the central and peripheral nervous system using innovative technologies such as the microtome, which he invented. 150 years after his resurrection of the classical germ layer theory of Wolff, von Baer and Remak, his description of the developmental origin of cranial and spinal ganglia from a distinct cell population, now known as the neural crest, has stood the test of time and more recently sparked tremendous advances regarding the molecular development of these important cells. In addition to his 1868 treatise on 'Zwischenstrang' (now neural crest), his work on the development of the human hindbrain published in 1890 provided novel ideas that more than 100 years later form the basis for penetrating molecular investigations of the regionalization of the hindbrain neural tube and of the migration and differentiation of its constituent neuron populations. In the first part of this review we briefly summarize the major discoveries of Wilhelm His and his impact on the field of embryology. In the second part we relate His' observations to current knowledge about the molecular underpinnings of hindbrain development and evolution. We conclude with the proposition, present already in rudimentary form in the writings of His, that a primordial spinal cord-like organization has been molecularly supplemented to generate hindbrain 'neomorphs' such as the cerebellum and the auditory and vestibular nuclei and their associated afferents and sensory organs.

Cerebellum

History, 17th Century

Neural Crest - cytology

Neural Tube

Neurons

Humans

History, 18th Century

Germ Layers

Rhombencephalon - physiology

Organogenesis

Biological Evolution

Rhombencephalon - cytology

Animals

Neural Crest - embryology

Body Patterning

Cell Differentiation

Ganglia, Spinal

Rhombencephalon - embryology

Details

Title: Subtitle: Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution
Creators: Joel C Glover - Department of Molecular Medicine, University of Oslo, Oslo, Norway; Norwegian Center for Stem Cell Research, Oslo University Hospital, Oslo, Norway; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway. Electronic address: joel.glover@medisin.uioo.no
Karen L Elliott - Department of Biology, University of Iowa, Iowa, IA 52242, USA
Albert Erives - Department of Biology, University of Iowa, Iowa, IA 52242, USA
Victor V Chizhikov - The University of Tennessee Health Science Center, Memphis, TN 38163, USA
Bernd Fritzsch - Department of Biology, University of Iowa, Iowa, IA 52242, USA. Electronic address: bernd-fritzsch@uiowa.edu
Resource Type: Journal article
Publication Details: Developmental biology, Vol.444 Suppl 1(Suppl 1), pp.S14-S24
DOI: 10.1016/j.ydbio.2018.02.001
PMID: 29447907
PMCID: PMC6087689
NLM abbreviation: Dev Biol
ISSN: 0012-1606
eISSN: 1095-564X
Publisher: United States
Grant note: R01 DC005590 / NIDCD NIH HHS R03 DC015333 / NIDCD NIH HHS R01 NS093009 / NINDS NIH HHS
Language: English
Date published: 12/01/2018
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9983991961002771

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