Journal article
Wireless fast-scan cyclic voltammetry measurement of histamine using WINCS - a proof-of-principle study
Analyst (London), Vol.137(9), pp.2158-2165
05/07/2012
DOI: 10.1039/c2an16038b
PMCID: PMC3360524
PMID: 22416270
Abstract
Histamine is among the most poorly understood biogenic amines, yet the histaminergic system spreads throughout the brain and has been implicated in functions as diverse as homeostasis and synaptic plasticity. Not surprisingly then, it has been linked to a number of conditions including minimally conscious state, persistent vegetative state, epilepsy, addiction, cluster headache, essential tremor, and Parkinson's disease. We have previously reported that the Wireless Instantaneous Neurotransmitter Concentration Sensing (WINCS) system can monitor dopamine, serotonin, and adenosine using fast-scan cyclic voltammetry (FSCV). Here, we demonstrate the expanded capability of the WINCS system to measure histamine. The optimal FSCV waveform was determined to be a triangle wave scanned between 0.4 and +1.4 V at a rate of 400 V s(-1) applied at 10 Hz. Using this optimized FSCV parameter, we found histamine release was induced by high frequency electrical stimulation at the tuberomammillary nucleus in rat brain slices. Our results suggest that the WINCS system can provide reliable, high fidelity measurements of histamine, consistently showing oxidative currents at +1.3 V, a finding that may have important clinical implications.
Details
- Title: Subtitle
- Wireless fast-scan cyclic voltammetry measurement of histamine using WINCS - a proof-of-principle study
- Creators
- Su-Youne Chang - Mayo ClinicTaylor Jay - Massachusetts Institute of TechnologyJoel Munoz - Univ Puerto Rico, Dept Med, San Juan, PR 00936 USAInyong Kim - Mayo ClinicKendall H. Lee - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Analyst (London), Vol.137(9), pp.2158-2165
- DOI
- 10.1039/c2an16038b
- PMID
- 22416270
- PMCID
- PMC3360524
- NLM abbreviation
- Analyst
- ISSN
- 0003-2654
- eISSN
- 1364-5528
- Publisher
- Royal Soc Chemistry
- Number of pages
- 8
- Grant note
- K08 NS 52232; R01 NS 70872; R01 NS 75013 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K08NS052232 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 05/07/2012
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9985112881002771
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