Journal article
Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development
Results and problems in cell differentiation, Vol.61, pp.83-114
2017
DOI: 10.1007/978-3-319-53150-2_4
PMCID: PMC6057142
PMID: 28409301
Abstract
Asymmetric cell division is a common mode of cell differentiation during the invariant lineage of the nematode, C. elegans. Beginning at the four-cell stage, and continuing throughout embryogenesis and larval development, mother cells are polarized by Wnt ligands, causing an asymmetric inheritance of key members of a Wnt/β-catenin signal transduction pathway termed the Wnt/β-catenin asymmetry pathway. The resulting daughter cells are distinct at birth with one daughter cell activating Wnt target gene expression via β-catenin activation of TCF, while the other daughter displays transcriptional repression of these target genes. Here, we seek to review the body of evidence underlying a unified model for Wnt-driven asymmetric cell division in C. elegans, identify global themes that occur during asymmetric cell division, as well as highlight tissue-specific variations. We also discuss outstanding questions that remain unanswered regarding this intriguing mode of asymmetric cell division.
Details
- Title: Subtitle
- Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development
- Creators
- Arielle Koonyee Lam - Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA, USABryan T Phillips - Department of Biology, University of Iowa, Iowa City, IA, USA. bryan-phillips@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Results and problems in cell differentiation, Vol.61, pp.83-114
- DOI
- 10.1007/978-3-319-53150-2_4
- PMID
- 28409301
- PMCID
- PMC6057142
- NLM abbreviation
- Results Probl Cell Differ
- eISBN
- 9783319531502; 3319531506
- ISSN
- 0080-1844
- eISSN
- 1861-0412
- Grant note
- R01 GM114007 / NIGMS NIH HHS
- Language
- English
- Date published
- 2017
- Academic Unit
- Biology
- Record Identifier
- 9984217427002771
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