Journal article
Wnt signaling as potential therapeutic target in lung cancer
Expert opinion on therapeutic targets, Vol.20(8), pp.999-1015
08/02/2016
DOI: 10.1517/14728222.2016.1154945
PMID: 26882052
Abstract
Introduction: Wingless-type (Wnt) signaling is tightly regulated at multiple cellular levels and is dysregulated in lung cancer. Therefore, it offers therapeutic targets for developing novel agents for lung cancer treatment.
Areas covered: In this article, we discuss the role of the Wnt signaling pathway in lung cancer, highlighting the aberrant activation of Wnt in lung cancer stem cells and its implication in resistance to radiotherapy, chemotherapy and targeted therapy. We also expound the regulatory roles of microRNAs in Wnt signaling, as well as the potential of the Wnt pathway to provide biomarkers and therapeutic targets in lung cancer. The potential use of small molecule and biological inhibitors targeting the Wnt pathway for lung cancer therapy and prevention is also discussed.
Expert opinion: Wnt signaling plays an important role in the development and metastasis of lung cancer; the pathway provides targets to develop agents towards for cancer prevention and therapy. A number of clinical trials have shown the effectiveness of Wnt pathway inhibitors in epithelial tumors. However, the side effects should be considered. Nevertheless, the results from clinical studies suggest that inhibitors targeting the Wnt signaling show promise against lung cancer.
Details
- Title: Subtitle
- Wnt signaling as potential therapeutic target in lung cancer
- Creators
- Jiali Yang - Ningxia Key laboratory of Clinical and Pathogenic Microbiology, Center of Laboratory Medicine of General Hospital at Ningxia Medical UniversityJuan Chen - Department of Pulmonary and Critical Care Medicine, General Hospital, Ningxia Medical UniversityJinxi He - Department of Thoracic Surgery, General Hospital, Ningxia Medical UniversityJing Li - Department of Thoracic Surgery, General Hospital, Ningxia Medical UniversityJuan Shi - Ningxia Key laboratory of Clinical and Pathogenic Microbiology, Center of Laboratory Medicine of General Hospital at Ningxia Medical UniversityWilliam C Cho - Department of Clinical Oncology, Queen Elizabeth HospitalXiaoming Liu - Human Stem Cell Institute, General Hospital, Ningxia Medical University
- Resource Type
- Journal article
- Publication Details
- Expert opinion on therapeutic targets, Vol.20(8), pp.999-1015
- Publisher
- Taylor & Francis
- DOI
- 10.1517/14728222.2016.1154945
- PMID
- 26882052
- ISSN
- 1472-8222
- eISSN
- 1744-7631
- Language
- English
- Date published
- 08/02/2016
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984025359302771
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