Journal article
Women Hospitalized for Acute on Chronic Decompensated Systolic Heart Failure Receive Less Furosemide Compared to Men
Cardiology research and practice, Vol.2019, pp.1-5
09/12/2019
DOI: 10.1155/2019/1505142
PMCID: PMC6757247
PMID: 31612080
Abstract
The cumulative incidence of systolic heart failure is similar in men and women. However, major prognostic differences exist between genders. We sought to measure gender differences in furosemide prescribing patterns for patients with preexisting heart failure with reduced ejection fraction (HFrEF) admitted with Stage C acute decompensation, regardless of the underlying cause. We conducted a single-center retrospective analysis of patients admitted between 2015 and 2018 for acute on chronic decompensated HFrEF. Primary outcomes were differences in initial furosemide dose, total dose over the first 24 hours of hospitalization, and total dose during the entire hospitalization between women and men. Secondary outcomes included acute kidney injury (AKI), intubation, noninvasive ventilation (NIV), and in-hospital 30-day and 1-year mortality. We studied 434 patients (31% female) with similar baseline characteristics. Females received significantly less furosemide compared to men for the initial dose, over the first 24 hours, and throughout their hospitalization. However, AKI was more prevalent in women versus men (
p
=
0.008
). Females admitted for acute on chronic decompensated HFrEF receive significantly less furosemide when compared to men, but developed more AKI prior to discharge.
Details
- Title: Subtitle
- Women Hospitalized for Acute on Chronic Decompensated Systolic Heart Failure Receive Less Furosemide Compared to Men
- Creators
- Tyler P. Rasmussen - Roy J. and Lucille A. Carver College of MedicineNoah N. Williford - Roy J. and Lucille A. Carver College of MedicineChristopher DeZorzi - Roy J. and Lucille A. Carver College of MedicineAziz Hammoud - Roy J. and Lucille A. Carver College of MedicineBrenden J. Boyle - Roy J. and Lucille A. Carver College of MedicineYunshu Zhou - University of IowaPatrick Ten Eyck - Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA 52242, USAMilena A. Gebska - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Cardiology research and practice, Vol.2019, pp.1-5
- DOI
- 10.1155/2019/1505142
- PMID
- 31612080
- PMCID
- PMC6757247
- NLM abbreviation
- Cardiol Res Pract
- ISSN
- 2090-8016
- eISSN
- 2090-0597
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: UL1TR002537
- Language
- English
- Date published
- 09/12/2019
- Academic Unit
- Biostatistics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359881402771
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