Journal article
Women's Reproductive History and Pre-Clinical Peripheral Arterial Disease in Late Life: The San Diego Population Study
Journal of women's health (Larchmont, N.Y. 2002), Vol.28(8), pp.1105-1115
08/2019
DOI: 10.1089/jwh.2018.7080
PMCID: 6703238
PMID: 30508411
Abstract
Reproductive events have been linked with increased cardiovascular risk in women, but whether they are associated with pre-clinical peripheral arterial disease (PAD) has been understudied. We evaluated associations between reproductive factors and later-life ankle-brachial index (ABI), femoral artery intima-media thickness (fIMT), and femoral plaques.
Cross-sectional analysis of 707 multiethnic women who participated in a follow-up exam of the San Diego Population Study in 2007-2011. To assess associations between reproductive factors (age at menarche, parity, age at menopause, surgical menopause, hormone therapy) with ABI, and Doppler ultrasound measurements of common and superficial fIMT, linear regression was used; for femoral plaque presence, logistic regression was used. Models were adjusted for age, race/ethnicity, and cardiometabolic factors. We tested interactions of reproductive factors with menopause type (natural vs. surgical).
Women were on average 71 years old, and 56% were non-Hispanic White. Reproductive factors were not associated with fIMT, femoral plaque presence, or ABI. There were significant interactions between menopause type (surgical vs. natural) and oral contraceptive use (-β: 0.04,
= 0.03) for ABI, as well as between menopause type and parity (β: 0.11,
= 0.05) and age at menopause (β: 0.001,
= 0.05) for fIMT. Among women with natural menopause, oral contraceptive use was associated with higher ABI (β: 0.03,
= 0.007) and older age at natural menopause was related to greater fIMT (β: 0.009,
= 0.06). Among women with surgical menopause, nulliparity was marginally associated with greater fIMT (β: 0.33,
= 0.07).
Reproductive history may not be independently associated with later-life lower extremity atherosclerosis in women. Studies are necessary to confirm findings and examine pregnancy-related exposures in relation to pre-clinical PAD.
Details
- Title: Subtitle
- Women's Reproductive History and Pre-Clinical Peripheral Arterial Disease in Late Life: The San Diego Population Study
- Creators
- Yamnia I Cortés - University of North Carolina at Chapel HillNisha Parikh - University of California, San FranciscoMatthew A Allison - University of California, San DiegoMichael H Criqui - University of California, San DiegoNatalie Suder - University of PittsburghEmma Barinas-Mitchell - University of PittsburghChristina L Wassel - Premier Research Group
- Resource Type
- Journal article
- Publication Details
- Journal of women's health (Larchmont, N.Y. 2002), Vol.28(8), pp.1105-1115
- DOI
- 10.1089/jwh.2018.7080
- PMID
- 30508411
- PMCID
- 6703238
- ISSN
- 1540-9996
- eISSN
- 1931-843X
- Grant note
- R01 HL110955 / NHLBI NIH HHS R01 HL053487 / NHLBI NIH HHS T32 HL083825 / NHLBI NIH HHS M01 RR000827 / NCRR NIH HHS
- Language
- English
- Date published
- 08/2019
- Academic Unit
- Nursing
- Record Identifier
- 9984446439602771
Metrics
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