Journal article
Working Group Report 3: Sensitivity to organic dusts-atopy and gene polymorphisms
American journal of industrial medicine, Vol.46(4), pp.416-418
10/2004
DOI: 10.1002/ajim.20065
PMID: 15376221
Abstract
Working Group 3 (Sensitivity to Organic Dusts-Atopy and Gene Polymorphisms) was convened to review the current understanding of how effects of inhaled organic dust may be modified by genetic factors-both those that increase as well as those that may reduce susceptibility. Furthermore, the group was asked to suggest areas that require more investigation in this field. The discussion focused on individual sensitivity to inhaled agents as the most important determinant of inter-individual heterogeneiety in responses to exposures. Genetic modifiers are known for a number of pathologic conditions (including asthma, atopy, chronic obstructive pulmonary disease, and hypersensitivity pneumonitis) associated with inhalation of organic dusts; modifiers are likely to be identified for a number of other disease states. Further studies are required to delineate more precisely the contribution (and the role in inflammatory cascade modulation) of these known polymorphisms, as well as to identify novel genetic factors.
Details
- Title: Subtitle
- Working Group Report 3: Sensitivity to organic dusts-atopy and gene polymorphisms
- Creators
- Joel N Kline - Department of Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, Iowa City, IowaGert Doekes - Institute of Risk Assessment Sciences, Utrecht, The NetherlandsJakob Bønløkke - Institute of Environmental and Occupational Medicine, University of Aarhus, Aarhus, DenmarkHans Jürgen Hoffman - Department of Respiratory Medicine, Aarhus University Hospital, Aarhus, DenmarkSusanna Von Essen - Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, OmahaRihong Zhai - Institute of Occupational Health, Nanning 530021, PR China
- Resource Type
- Journal article
- Publication Details
- American journal of industrial medicine, Vol.46(4), pp.416-418
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/ajim.20065
- PMID
- 15376221
- ISSN
- 0271-3586
- eISSN
- 1097-0274
- Number of pages
- 3
- Language
- English
- Date published
- 10/2004
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984094741302771
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