Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum

Nancy C Andreasen; Richard Carson; Mirko Diksic; Alan  Evans; Lars Farde; Albert Gjedde; Antoine Hakim; Samarthji Lal; Neelakanta Nair; Göran Sedvall

doi:10.1093/schbul/14.3.471

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Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum

Journal article

Open access

Peer reviewed

Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum

Nancy C Andreasen, Richard Carson, Mirko Diksic, Alan Evans, Lars Farde, Albert Gjedde, Antoine Hakim, Samarthji Lal, Neelakanta Nair and Göran Sedvall

Schizophrenia bulletin, Vol.14(3), pp.471-485

1988

DOI: 10.1093/schbul/14.3.471

PMID: 2975043

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Abstract

Recently, two research groups published numbers for D2 receptor sites in the neostriatum of drug-naive schizophrenic patients, obtained in vivo by positron emission tomography (PET). One study appeared to confirm the increase of D2 receptor numbers, while the other study did not. A workshop was convened in Montreal to examine the reasons for the discrepancy between the results obtained by the two groups. The workshop considered patient populations, PET instrumentation and scanning methods, pharmacology, and modeling. The workshop identified differences between the approaches of the two groups that could contribute to the divergent results, including age and chronicity of the patient samples, brain region selected for study, metabolism of the different radioligands in blood and brain, reversibility of binding, PET instrumentation, and complexity of data analysis. The workshop concluded that these initial efforts had made considerable progress in establishing the role of PET in the understanding of the biochemical processes underlying mental illness. In particular, the unique ability to quantify regional neuroreceptor density at different stages in the evolution of the disease has been implemented. At the same time, the work so far and this conference served to identify the main sources contributing to the different findings from the two centers. This information will be important in designing the next phase of the research which will build upon and reconcile these apparent discrepancies.

United States

Raclopride

Corpus Striatum - physiopathology

Humans

Haloperidol - pharmacokinetics

Schizophrenic Psychology

Spiperone - pharmacokinetics

Spiperone - analogs & derivatives

National Institute of Mental Health (U.S.)

Schizophrenia - physiopathology

Receptors, Dopamine D2

Adult

Tomography, Emission-Computed

Salicylamides - pharmacokinetics

Receptors, Dopamine - physiology

Details

Title: Subtitle: Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum
Creators: Nancy C Andreasen
Richard Carson
Mirko Diksic
Alan Evans
Lars Farde
Albert Gjedde
Antoine Hakim
Samarthji Lal
Neelakanta Nair
Göran Sedvall
Resource Type: Journal article
Publication Details: Schizophrenia bulletin, Vol.14(3), pp.471-485
Publisher: United States
DOI: 10.1093/schbul/14.3.471
PMID: 2975043
ISSN: 0586-7614
eISSN: 1745-1701
Language: English
Date published: 1988
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003483902771

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