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Workup of Gastroenteropancreatic Neuroendocrine Tumors
Journal article   Open access   Peer reviewed

Workup of Gastroenteropancreatic Neuroendocrine Tumors

Joseph S. Dillon
Surgical oncology clinics of North America, Vol.29(2), pp.165-183
04/2020
DOI: 10.1016/j.soc.2019.10.002
PMCID: PMC7243465
PMID: 32151354
url
https://www.ncbi.nlm.nih.gov/pmc/articles/7243465View
Open Access

Abstract

Neuroendocrine tumors of the gastrointestinal tract or pancreas are rare. Their presentation overlaps with other intra-abdominal neoplasms, but can have unique features. The workup involves recognition of unusual clinical features associated with the tumors, imaging, analysis of blood or urine concentrations, and biopsy. Functional imaging takes advantage of the neuroendocrine tumor-specific expression of somatostatin receptors. There are characteristic features supporting the diagnosis on contrast-enhanced cross-sectional imaging. The use of tumor markers for biochemical diagnosis requires an understanding of the confounding variables affecting these assays. There are unique and specific immunohistochemical staining and grading requirements for appropriate diagnosis of these tumors.
Biopsy Clinical presentation Gastroenteropancreatic neuroendocrine tumors Imaging Tumor markers

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