Journal article
X-ray attenuation coefficients of high-atomic-number, hexanuclear transition metal cluster compounds: A new paradigm for radiographic contrast agents
Academic radiology, Vol.7(4), pp.254-259
2000
DOI: 10.1016/S1076-6332(00)80475-4
PMID: 10766098
Abstract
The purpose of this study was to examine the radiologic attenuation properties of the parent cluster compounds, particularly attenuation as a function of discrete photon energy, before investigating ligand substitutions, which are necessary to improve cluster biocompatibility and to impart desirable physicochemical properties.
The linear attenuation coefficients for solutions of the cluster compounds Ta
6Br
14, K
8Ta
6O
19, and (H
3O)
2W
6Cl
14 were determined at 60, 80, 103, 122, and 140 keV from gamma-ray transmission measurements with americium-241, xenon-133, gadolinium-153, cobalt-57, and technetium-99m radioactive sources. Transmission measurements were obtained for a fixed time interval that ensured a statistically accurate count distribution exceeding 20,000 counts through the sample for each trial.
On a strictly mole per liter basis, a 0.075 mol/L aqueous solution of K
8Ta
6O
19 showed 1.08 times the attenuation of 0.063 mol/L aqueous iohexol at 60 keV and 3.30 times the attenuation at 80 keV. Similarly, a 0.05 mol/L methanolic solution of (H
3O)
2W
6Cl
14 showed 0.96 times (96%) the attenuation of 0.063 mol/L aqueous iohexol at 60 keV but 3.09 times the attenuation of the iohexol solution at 80 keV. Attenuations of 0.063 mol/L aqueous iohexol and 0.0125 mol/L Ta
6Br
14 (ie, at approximately one-fifth the iohexol concentration) were comparable at greater than 60 keV.
These results confirm the theoretic potential for use of early transition metal cluster compounds as radiographic contrast agents. At higher x-ray energies, cluster compounds demonstrate multiplied x-ray attenuation relative to iodinated contrast agents.
Details
- Title: Subtitle
- X-ray attenuation coefficients of high-atomic-number, hexanuclear transition metal cluster compounds: A new paradigm for radiographic contrast agents
- Creators
- Brian F Mullan - From the Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242-1077, USAMark T Madsen - From the Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242-1077, USALouis Messerle - the Department of Chemistry, University of Iowa, Iowa City, USAVladimir Kolesnichenko - the Department of Chemistry, University of Iowa, Iowa City, USAJason Kruger - the Department of Chemistry, University of Iowa, Iowa City, USA
- Resource Type
- Journal article
- Publication Details
- Academic radiology, Vol.7(4), pp.254-259
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1076-6332(00)80475-4
- PMID
- 10766098
- ISSN
- 1076-6332
- eISSN
- 1878-4046
- Language
- English
- Date published
- 2000
- Academic Unit
- Radiology; Chemistry; Internal Medicine
- Record Identifier
- 9984094603802771
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