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Xanthoma disseminatum and Waldenström's macroglobulinemia
Journal article

Xanthoma disseminatum and Waldenström's macroglobulinemia

M E Goodenberger, W W Piette, D E Macfarlane and Z B Argenyi
Journal of the American Academy of Dermatology, Vol.23(5 Pt 2), pp.1015-1018
11/1990
DOI: 10.1016/0190-9622(90)70326-D
PMID: 2121806

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Abstract

A 71-year-old woman had a 7-month history of multiple asymptomatic papules on the upper part of the body. The clinical picture and histopathologic findings confirmed the diagnosis of xanthoma disseminatum. Further studies revealed Waldenström's macroglobulinemia. Treatment with chlorambucil and prednisone led to a dramatic reduction in her paraprotein level. In addition, cutaneous lesions improved and new lesions stopped appearing. Treatment of selected papules by cryotherapy or intralesional corticosteroid injection provided further improvement. This case is notable because (1) it is the first report of xanthoma disseminatum in a patient with Waldenström's macroglobulinemia and (2) there was an unusually good response to therapy.
Histiocytosis, Non-Langerhans-Cell - pathology Skin Diseases - complications Waldenstrom Macroglobulinemia - complications Histiocytosis, Non-Langerhans-Cell - complications Waldenstrom Macroglobulinemia - therapy Humans Female Aged Histiocytosis, Non-Langerhans-Cell - therapy Skin Diseases - pathology Skin - pathology

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