Journal article
YET ANOTHER USE FOR BOTULINUM TOXIN? IN PLACE OF PYLORIC DRAINAGE PROCEDURES AFTER ESOPHAGECTOMY
Evidence-based gastroenterology, Vol.8(3), pp.59-60
08/2007
DOI: 10.1097/EBG.0b013e3181462f10
Abstract
Objective
To evaluate the effect of injecting the pylorus with botulinum toxin (BoTox) on gastric emptying after esophagectomy.
Design
Retrospective review
Setting
University Medical Center and Community Teaching Hospital in United States.
Patients
Patients who had BoTox injected at the time of esophagectomy (n=12) and patients who presented with delayed gastric emptying after esophagectomy with either no or inadequate pyloric drainage performed at the time of surgery (n=3).
Intervention
Injection of pylorus with BoTox.
Main Outcome Measures
Nuclear gastric emptying scan, barium swallow, occurrence of aspiration pneumonia, and resumption of oral intake.
Results
Fifteen patients who had BoTox injection at the time or shortly afterwards of esophagectomy were studied. Twelve patients had undergone BoTox injection at the time of esophagectomy, and 3 patients were treated endoscopically after surgery. Eight of these patients underwent a nuclear emptying scan at a median of 4.2 months after surgery, which showed a mean emptying half-life of 100 minutes (range, 31 to 196 min). With a median follow-up of 5.3 months, 1 patient (8%) required reintervention for symptoms of gastric stasis. All 3 patients injected postoperatively demonstrated an improvement in symptoms of gastric outlet obstruction and were able to resume a regular diet.
Conclusion(S)
BoTox can be safely injected into the pylorus in patients undergoing esophagectomy and can potentially alleviate the problems of delayed gastric emptying in early postoperative period.
Details
- Title: Subtitle
- YET ANOTHER USE FOR BOTULINUM TOXIN? IN PLACE OF PYLORIC DRAINAGE PROCEDURES AFTER ESOPHAGECTOMY
- Creators
- Sajida Ahad - University of WashingtonBrant K. Oelschlager - University of Washington
- Resource Type
- Journal article
- Publication Details
- Evidence-based gastroenterology, Vol.8(3), pp.59-60
- DOI
- 10.1097/EBG.0b013e3181462f10
- ISSN
- 1527-8557
- eISSN
- 1537-1581
- Language
- English
- Date published
- 08/2007
- Academic Unit
- Surgery
- Record Identifier
- 9984322798102771
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