Journal article
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins
Genes & development, Vol.3(3), pp.283-292
1989
DOI: 10.1101/gad.3.3.283
PMID: 2542125
Abstract
The jun family of transcriptional activators includes mammalian AP-1 as well as the yeast regulatory protein GCN4. Recently, an additional transcriptional activator has been found in yeast that recognizes the TGACTCA sequence element common in GCN4/AP-1 sites. This factor was designated yAP-1. The structural gene for yAP-1 has now been isolated and characterized. The deduced amino acid sequence predicts a protein of 650 residues, considerably larger than GCN4 or c-Jun. The amino terminus of yAP-1 is homologous to the carboxy-terminal DNA-binding domains of GCN4 and c-Jun. Disruption of the YAP1 gene demonstrates this gene is not essential but is required for AP-1 recognition element-dependent transcriptional activation. DNA-affinity blots of proteins from YAP1 cells suggest the presence of additional TGACTCA-binding proteins other than GCN4 and yAP-1. Furthermore, expression of at least one of these related DNA-binding proteins appears to be under control of yAP-1.
Details
- Title: Subtitle
- Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins
- Creators
- W Scott Moye-Rowley - California inst. technology, Pasadena CA 91125, United StatesKeith D Harshman - California inst. technology, Pasadena CA 91125, United StatesCarl S Parker - California inst. technology, Pasadena CA 91125, United States
- Resource Type
- Journal article
- Publication Details
- Genes & development, Vol.3(3), pp.283-292
- DOI
- 10.1101/gad.3.3.283
- PMID
- 2542125
- NLM abbreviation
- Genes Dev
- ISSN
- 0890-9369
- eISSN
- 1549-5477
- Publisher
- Cold Spring Harbor Laboratory
- Language
- English
- Date published
- 1989
- Academic Unit
- Molecular Physiology and Biophysics; Internal Medicine
- Record Identifier
- 9984297612002771
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