Yellow fever virus exhibits slower evolutionary dynamics than dengue virus

Amadou A Sall; Ousmane Faye; Mawlouth Diallo; Cadhla Firth; Andrew Kitchen; Edward C Holmes

doi:10.1128/JVI.01738-09

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Yellow fever virus exhibits slower evolutionary dynamics than dengue virus

Journal article

Open access

Peer reviewed

Yellow fever virus exhibits slower evolutionary dynamics than dengue virus

Amadou A Sall, Ousmane Faye, Mawlouth Diallo, Cadhla Firth, Andrew Kitchen and Edward C Holmes

Journal of virology, Vol.84(2), pp.765-772

01/2010

DOI: 10.1128/JVI.01738-09

PMCID: PMC2798388

PMID: 19889759

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Abstract

Although yellow fever has historically been one of the most important viral infections of humans, relatively little is known about the evolutionary processes that shape its genetic diversity. Similarly, there is limited information on the molecular epidemiology of yellow fever virus (YFV) in Africa even though it most likely first emerged on this continent. Through an analysis of complete E gene sequences, including a newly acquired viral collection from Central and West Africa (Senegal, Cameroon, Central African Republic, Côte d'Ivoire, Mali, and Mauritania), we show that YFV exhibits markedly lower rates of evolutionary change than dengue virus, despite numerous biological similarities between these two viruses. From this observation, along with a lack of clock-like evolutionary behavior in YFV, we suggest that vertical transmission, itself characterized by lower replication rates, may play an important role in the evolution of YFV in its enzootic setting. Despite a reduced rate of nucleotide substitution, phylogenetic patterns and estimates of times to common ancestry in YFV still accord well with the dual histories of colonialism and the slave trade, with areas of sylvatic transmission (such as Kedougou, Senegal) acting as enzootic/epidemic foci.

Viral Envelope Proteins - genetics

Yellow fever virus - isolation & purification

Humans

Selection, Genetic

Molecular Sequence Data

Dengue - virology

Phylogeny

Sequence Analysis, DNA

Dengue Virus - genetics

Animals

Yellow Fever - virology

Senegal

Viral Envelope Proteins - chemistry

Bayes Theorem

Dengue Virus - isolation & purification

Evolution, Molecular

Yellow fever virus - genetics

Details

Title: Subtitle: Yellow fever virus exhibits slower evolutionary dynamics than dengue virus
Creators: Amadou A Sall - Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal
Ousmane Faye
Mawlouth Diallo
Cadhla Firth
Andrew Kitchen
Edward C Holmes
Resource Type: Journal article
Publication Details: Journal of virology, Vol.84(2), pp.765-772
DOI: 10.1128/JVI.01738-09
PMID: 19889759
PMCID: PMC2798388
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: United States
Grant note: R01 GM080533 / NIGMS NIH HHS GM080533 / NIGMS NIH HHS
Language: English
Date published: 01/2010
Academic Unit: Anthropology; International Programs
Record Identifier: 9983983655602771

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