Journal article
Yes! Sex matters: sex, the brain and blood pressure
Current hypertension reports, Vol.16(8), pp.458-9
08/2014
DOI: 10.1007/s11906-014-0458-4
PMCID: PMC4081455
PMID: 24929952
Abstract
The role of the brain in hypertension between the sexes is known to be important especially with regards to the effects of circulating sex hormones. A number of different brain regions important for regulation of sympathetic outflow and blood pressure express estrogen receptors (ERα and ERβ). Estradiol, acting predominantly via the ERα, inhibits angiotensin II activation of the area postrema and subfornical organ neurons and inhibits reactive oxygen generation that is required for the development of Angiotensin II-induced neurogenic hypertension. Estradiol activation of ERβ within the paraventricular nucleus and the rostral ventral lateral medulla inhibits these neurons and inhibits angiotensin II, or aldosterone induced increases in sympathetic outflow and hypertension. Understanding the cellular and molecular mechanisms underlying ERα and ERβ actions within key brain regions regulating blood pressure will be essential for the development of "next generation" selective estrogen receptor modulators (SERMS) that can be used clinically for the treatment of neurogenic hypertension.
Details
- Title: Subtitle
- Yes! Sex matters: sex, the brain and blood pressure
- Creators
- Meredith Hay - Department of Physiology, University of Arizona, 1501 N Campbell Rd Bldg 201, Rm 4103, Tucson, AZ, 85724, USA, mhay@arizona.eduBaojian XueAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.16(8), pp.458-9
- DOI
- 10.1007/s11906-014-0458-4
- PMID
- 24929952
- PMCID
- PMC4081455
- NLM abbreviation
- Curr Hypertens Rep
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Publisher
- Springer Science and Business Media LLC; United States
- Grant note
- P01 HL014388 / NHLBI NIH HHS R01 MH080241 / NIMH NIH HHS MH-80241 / NIMH NIH HHS R01 HL098207 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL-98207 / NHLBI NIH HHS
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health, Sport, and Human Physiology
- Record Identifier
- 9984002460902771
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