Journal article
You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria
Trends in parasitology, Vol.36(2), pp.147-157
02/2020
DOI: 10.1016/j.pt.2019.11.004
PMCID: PMC6937381
PMID: 31843536
Abstract
Each year over 200 million malaria infections occur, with over 400 000 associated deaths. Vaccines formed with attenuated whole parasites can induce protective memory CD8 T cell responses against liver-stage malaria; however, widespread administration of such vaccines is logistically challenging. Recent scientific findings are delineating how protective memory CD8 T cell populations are primed and maintained and how such cells mediate immunity to liver-stage malaria. Memory CD8 T cell anatomic localization and expression of transcription factors, homing receptors, and signaling molecules appear to play integral roles in protective immunity to liver-stage malaria. Further investigation of how such factors contribute to optimal protective memory CD8 T cell generation and maintenance in humans will inform efforts for improved vaccines.
Details
- Title: Subtitle
- You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria
- Creators
- Mitchell N Lefebvre - University of IowaJohn T Harty - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Trends in parasitology, Vol.36(2), pp.147-157
- DOI
- 10.1016/j.pt.2019.11.004
- PMID
- 31843536
- PMCID
- PMC6937381
- NLM abbreviation
- Trends Parasitol
- ISSN
- 1471-4922
- eISSN
- 1471-5007
- Grant note
- R01 AI114543 / NIAID NIH HHS R37 AI042767 / NIAID NIH HHS R01 AI100527 / NIAID NIH HHS T32 GM007337 / NIGMS NIH HHS R01 AI042767 / NIAID NIH HHS R01 AI085515 / NIAID NIH HHS R21 AI042767 / NIAID NIH HHS
- Language
- English
- Date published
- 02/2020
- Academic Unit
- Pathology
- Record Identifier
- 9984186657502771
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