Journal article
Youth Appraisals of Inter-parental Conflict and Genetic and Environmental Contributions to Attention-Deficit Hyperactivity Disorder: Examination of GxE Effects in a Twin Sample
Journal of abnormal child psychology, Vol.40(4), pp.543-554
05/2012
DOI: 10.1007/s10802-011-9583-6
PMID: 22006350
Abstract
Identification of gene x environment interactions (GxE) for attention-deficit hyperactivity disorder (ADHD) is a crucial component to understanding the mechanisms underpinning the disorder, as prior work indicates large genetic influences and numerous environmental risk factors. Building on prior research, children’s appraisals of self-blame were examined as a psychosocial moderator of latent etiological influences on ADHD via biometric twin models, which provide an omnibus test of GxE while managing the potential confound of gene-environment correlation. Participants were 246 twin pairs (total n = 492) ages 6–16 years. ADHD behaviors were assessed via mother report on the Child Behavior Checklist. To assess level of self-blame, each twin completed the Children’s Perception of Inter-parental Conflict scale. Two biometric GxE models were fit to the data. The first model revealed a significant decrease in genetic effects and a significant increase in unique environmental influences on ADHD with increasing levels of self-blame. These results generally persisted even after controlling for confounding effects due to gene-environment correlation in the second model. Results suggest that appraisals of self-blame in relation to inter-parental conflict may act as a key moderator of etiological contributions to ADHD.
Details
- Title: Subtitle
- Youth Appraisals of Inter-parental Conflict and Genetic and Environmental Contributions to Attention-Deficit Hyperactivity Disorder: Examination of GxE Effects in a Twin Sample
- Creators
- Molly Nikolas - Department of Psychology University of Iowa E112 SSH Iowa City IA 52242 USAKelly Klump - Department of Psychology Michigan State University 107B Psychology Building East Lansing MI 48824 USAS Burt - Department of Psychology Michigan State University 107D Psychology Building East Lansing MI 48824 USA
- Resource Type
- Journal article
- Publication Details
- Journal of abnormal child psychology, Vol.40(4), pp.543-554
- DOI
- 10.1007/s10802-011-9583-6
- PMID
- 22006350
- NLM abbreviation
- J Abnorm Child Psychol
- ISSN
- 0091-0627
- eISSN
- 1573-2835
- Publisher
- Springer US; Boston
- Language
- English
- Date published
- 05/2012
- Academic Unit
- Psychological and Brain Sciences; Injury Prevention Research Center
- Record Identifier
- 9984002485602771
Metrics
17 Record Views