Youth Polygenic Scores, Youth ADHD Symptoms, and Parenting Dimensions: An Evocative Gene-Environment Correlation Study

Leiana de la Paz; Michael A Mooney; Peter Ryabinin; Christopher Neighbor; Dylan Antovich; Joel T Nigg; Molly A Nikolas

doi:10.1007/s10802-023-01024-5

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Youth Polygenic Scores, Youth ADHD Symptoms, and Parenting Dimensions: An Evocative Gene-Environment Correlation Study

Journal article

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Youth Polygenic Scores, Youth ADHD Symptoms, and Parenting Dimensions: An Evocative Gene-Environment Correlation Study

Leiana de la Paz, Michael A Mooney, Peter Ryabinin, Christopher Neighbor, Dylan Antovich, Joel T Nigg and Molly A Nikolas

Research on child and adolescent psychopathology, Vol.51(5), pp.655-677

05/2023

DOI: 10.1007/s10802-023-01024-5

PMCID: PMC10560546

PMID: 36645612

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10560546/pdf/nihms-1932966.pdfView

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Abstract

Parenting practices and parental symptoms of attention-deficit/hyperactivity disorder (ADHD) have been linked to severity and course of youth ADHD. However, genetically influenced behaviors related to ADHD in youth may also influence parenting behaviors. Polygenic scores (PGS) have been widely used to quantify genetic vulnerability for ADHD but has rarely been used to examine gene-environment correlation effects. The current study examined the direct effects of youth ADHD PGS and its evocative effects on parenting behaviors via youth ADHD symptoms. 803 youth aged 6-18 years (58.5% male) completed a multistage, multi-informant assessment that included measures of parenting practices and youth and parental ADHD symptoms. A mediation model was used to evaluate direct and evocative effects. Furthermore, we examined if these evocative effects remain after controlling for parental ADHD symptoms. Sensitivity analyses across age, sex, and socioeconomic status (SES) as well as restricting ancestry groups to European only ancestry were also conducted. Results indicated that youth ADHD PGS reliably predicted youth ADHD symptoms across all models (βs ranging from 0.18 to 0.26), including across age, sex, and SES and held even with ancestry restricted to the largest group (northern European). Evocative effects emerged such that higher youth PGS significantly predicted more youth ADHD symptoms, which in turn, significantly predicted lower levels of parental involvement and higher levels of poor supervision/monitoring and inconsistent discipline. These effects remained after controlling for parent ADHD symptoms.

Parenting

Gene-environment correlation

ADHD

Parental ADHD

Polygenic scores

Details

Title: Subtitle: Youth Polygenic Scores, Youth ADHD Symptoms, and Parenting Dimensions: An Evocative Gene-Environment Correlation Study
Creators: Leiana de la Paz - University of Iowa
Michael A Mooney - Oregon Health & Science University
Peter Ryabinin - Oregon Health & Science University
Christopher Neighbor - Division of Psychology, Department of Psychiatry, Portland, OR, USA.
Dylan Antovich - Division of Psychology, Department of Psychiatry, Portland, OR, USA.
Joel T Nigg - Division of Psychology, Department of Psychiatry, Portland, OR, USA.
Molly A Nikolas - Department of Psychological and Brain Sciences, G60 Psychological and Brain Sciences Bldg., 340 Iowa Ave, Iowa City, IA, 52242, USA.
Resource Type: Journal article
Publication Details: Research on child and adolescent psychopathology, Vol.51(5), pp.655-677
DOI: 10.1007/s10802-023-01024-5
PMID: 36645612
PMCID: PMC10560546
NLM abbreviation: Res Child Adolesc Psychopathol
ISSN: 2730-7166
eISSN: 2730-7174
Grant note: R01MH070004-01A2 / NIMH NIH HHS MH-R3759105 / NIMH NIH HHS
Language: English
Electronic publication date: 01/16/2023
Date published: 05/2023
Academic Unit: Psychological and Brain Sciences; Injury Prevention Research Center
Record Identifier: 9984360035702771

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