Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?

Mohammad Obeidat; Alexandra L Isaacson; Stephanie J Chen; Marina Ivanovic; Danniele Holanda

doi:10.1080/01913123.2020.1850966

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Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?

Journal article

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Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?

Mohammad Obeidat, Alexandra L Isaacson, Stephanie J Chen, Marina Ivanovic and Danniele Holanda

Ultrastructural pathology, Vol.44(4-6), pp.519-523

11/20/2020

DOI: 10.1080/01913123.2020.1850966

PMID: 33274661

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Abstract

COVID-19 (from SARS-CoV-2) is the cause of an ongoing pandemic, with an increasing number of cases and significant mortality worldwide. Clinical trials and extensive studies are being conducted on a large scale for a better understanding of the pathophysiology of this disease and its effect on different organs. Several experimental treatment protocols have been introduced, in which hydroxychloroquine (HCQ) was one of the first drugs used. While patients can develop many side effects of HCQ, studies have documented a rare association of long-term HCQ treatment with zebra-like bodies in the ultrastructural examination of kidney biopsies, a finding typically seen in Fabry's disease, as well as in association with chronic HCQ use, among other drugs. We present a similar finding in the postmortem examination of a male in his early seventies with COVID-19 infection, who received five days of HCQ treatment before stopping the medication due to cardiac and renal toxicity.

acute kidney injury

acute tubular injury

Covid-19

hydroxychloroquine

Pandemic

zebra bodies

Details

Title: Subtitle: Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?
Creators: Mohammad Obeidat - University of Iowa Hospitals and Clinics
Alexandra L Isaacson - University of Iowa Hospitals and Clinics
Stephanie J Chen - University of Iowa Hospitals and Clinics
Marina Ivanovic - University of Iowa Hospitals and Clinics
Danniele Holanda - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Ultrastructural pathology, Vol.44(4-6), pp.519-523
DOI: 10.1080/01913123.2020.1850966
PMID: 33274661
NLM abbreviation: Ultrastruct Pathol
ISSN: 0191-3123
eISSN: 1521-0758
Publisher: Taylor & Francis
Language: English
Date published: 11/20/2020
Academic Unit: Pathology
Record Identifier: 9984186439202771

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