Journal article
Zebrafish as an emerging tool for drug discovery and development for thyroid diseases
Fish & shellfish immunology, Vol.130, pp.53-60
11/2022
DOI: 10.1016/j.fsi.2022.09.001
PMID: 36084888
Abstract
Zebrafish is a useful model for understanding human genetics and diseases and has evolved into a prominent scientific research model. The genetic structure of zebrafish is 70% identical to that of humans. Its small size, low cost, and transparent embryo make it a valuable tool in experimentation. Zebrafish and mammals possess the same molecular mechanism of thyroid organogenesis and development. Thus, thyroid hormone signaling, embryonic development, thyroid-related disorders, and novel genes involved in early thyroid development can all be studied using zebrafish as a model. Here in this review, we emphasize the evolving role of zebrafish as a possible tool for studying the thyroid gland in the context of physiology and pathology. The transcription factors nkx2.1a, pax2a, and hhex which contribute a pivotal role in the differentiation of thyroid primordium are discussed. Further, we have described the role of zebrafish as a model for thyroid cancer, evaluation of defects in thyroid hormone transport, thyroid hormone (TH) metabolism, and as a screening tool to study thyrotoxins. Hence, the present review highlights the role of zebrafish as a novel approach to understand thyroid development and organogenesis.
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•Like mammals, zebrafish also possess the hypothalamus-pituitary-thyroid axis.•Thyroid hormone signaling is regulated by the hypothalamus-pituitary axis, deiodinases, and transporters.•Zebrafish is an evolving model to study thyroid hormone signaling and related disorders.•Zebrafish model could be utilized for discovering novel therapeutic tools.
Details
- Title: Subtitle
- Zebrafish as an emerging tool for drug discovery and development for thyroid diseases
- Creators
- Poonam Yadav - Central University of PunjabLopmudra P. Sarode - Rashtrasant Tukadoji Maharaj Nagpur UniversityRavinder Reddy Gaddam - University of IowaPuneet Kumar - Central University of PunjabJasvinder Singh Bhatti - Central University of PunjabAmit Khurana - RWTH Aachen UniversityUmashanker Navik - Central University of Punjab
- Resource Type
- Journal article
- Publication Details
- Fish & shellfish immunology, Vol.130, pp.53-60
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.fsi.2022.09.001
- PMID
- 36084888
- ISSN
- 1050-4648
- eISSN
- 1095-9947
- Language
- English
- Date published
- 11/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984446062602771
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