Journal article
Zika Virus Disease and Pregnancy Outcomes in Colombia
The New England journal of medicine, Vol.383(6), pp.537-545
08/06/2020
DOI: 10.1056/NEJMoa1911023
PMCID: 7480270
PMID: 32757522
Abstract
In 2015 and 2016, Colombia had a widespread outbreak of Zika virus. Data from two national population-based surveillance systems for symptomatic Zika virus disease (ZVD) and birth defects provided complementary information on the effect of the Zika virus outbreak on pregnancies and infant outcomes.
We collected national surveillance data regarding cases of pregnant women with ZVD that were reported during the period from June 2015 through July 2016. The presence of Zika virus RNA was identified in a subgroup of these women on real-time reverse-transcriptase-polymerase-chain-reaction (rRT-PCR) assay. Brain or eye defects in infants and fetuses and other adverse pregnancy outcomes were identified among the women who had laboratory-confirmed ZVD and for whom data were available regarding pregnancy outcomes. We compared the nationwide prevalence of brain and eye defects during the outbreak with the prevalence both before and after the outbreak period.
Of 18,117 pregnant women with ZVD, the presence of Zika virus was confirmed in 5926 (33%) on rRT-PCR. Of the 5673 pregnancies with laboratory-confirmed ZVD for which outcomes had been reported, 93 infants or fetuses (2%) had brain or eye defects. The incidence of brain or eye defects was higher among pregnancies in which the mother had an onset of ZVD symptoms in the first trimester than in those with an onset during the second or third trimester (3% vs. 1%). A total of 172 of 5673 pregnancies (3%) resulted in pregnancy loss; after the exclusion of pregnancies affected by birth defects, 409 of 5426 (8%) resulted in preterm birth and 333 of 5426 (6%) in low birth weight. The prevalence of brain or eye defects during the outbreak was 13 per 10,000 live births, as compared with a prevalence of 8 per 10,000 live births before the outbreak and 11 per 10,000 live births after the outbreak.
In pregnant women with laboratory-confirmed ZVD, brain or eye defects in infants or fetuses were more common during the Zika virus outbreak than during the periods immediately before and after the outbreak. The frequency of such defects was increased among women with a symptom onset early in pregnancy. (Funded by the Colombian Instituto Nacional de Salud and the Centers for Disease Control and Prevention.).
Details
- Title: Subtitle
- Zika Virus Disease and Pregnancy Outcomes in Colombia
- Creators
- Martha L Ospina - Instituto Nacional de SaludVan T Tong - Centers for Disease Control and PreventionMaritza Gonzalez - Instituto Nacional de SaludDiana Valencia - Centers for Disease Control and PreventionMarcela Mercado - Instituto Nacional de SaludSuzanne M Gilboa - Centers for Disease Control and PreventionAndrea J Rodriguez - Centers for Disease Control and PreventionSarah C Tinker - Centers for Disease Control and PreventionAngelica Rico - Instituto Nacional de SaludChristina M Winfield - Centers for Disease Control and PreventionLissethe Pardo - Centers for Disease Control and PreventionJennifer D Thomas - Centers for Disease Control and PreventionGreace Avila - Centers for Disease Control and PreventionJulie M Villanueva - Centers for Disease Control and PreventionSara Gomez - Centers for Disease Control and PreventionDenise J Jamieson - Centers for Disease Control and PreventionFranklyn Prieto - Centers for Disease Control and PreventionDana Meaney-Delman - Centers for Disease Control and PreventionOscar Pacheco - Centers for Disease Control and PreventionMargaret A Honein - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.383(6), pp.537-545
- DOI
- 10.1056/NEJMoa1911023
- PMID
- 32757522
- PMCID
- 7480270
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Grant note
- CC999999 / Intramural CDC HHS Interagency Agreement to CDC / United States Agency for International Development
- Language
- English
- Date published
- 08/06/2020
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446549102771
Metrics
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