Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

Juan-Carlos Saiz; Miguel A. Martin-Acebes; Ruben Bueno-Mari; Oscar D. Salomon; Luis C. Villamil-Jimenez; Jorg Heukelbach; Carlos H. Alencar; Paul K. Armstrong; Tania M. Ortiga-Carvalho; Rosalia Mendez-Otero; Paulo H. Rosado-de-Castro; Pedro M. Pimentel-Coelho

doi:10.3389/fmicb.2017.01554

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Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

Journal article

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Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

Juan-Carlos Saiz, Miguel A. Martin-Acebes, Ruben Bueno-Mari, Oscar D. Salomon, Luis C. Villamil-Jimenez, Jorg Heukelbach, Carlos H. Alencar, Paul K. Armstrong, Tania M. Ortiga-Carvalho, Rosalia Mendez-Otero, …

Frontiers in microbiology, Vol.8, p.1554

08/22/2017

DOI: 10.3389/fmicb.2017.01554

PMCID: PMC5572254

PMID: 28878742

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Abstract

Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.

Life Sciences & Biomedicine

Microbiology

Science & Technology

Details

Title: Subtitle: Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
Creators: Juan-Carlos Saiz - Inst Nacl Invest & Tecnol Agr & Alimentaria, Dept Biotechnol, Madrid, Spain
Miguel A. Martin-Acebes - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Ruben Bueno-Mari - Centro de Investigación y Desarrollo
Oscar D. Salomon - Instituto Nacional de Medicina Tropical
Luis C. Villamil-Jimenez - University of La Salle
Jorg Heukelbach - Universidade Federal do Ceará
Carlos H. Alencar - Universidade Federal do Ceará
Paul K. Armstrong - Government of Western Australia Department of Health
Tania M. Ortiga-Carvalho - Universidade Federal do Rio de Janeiro
Rosalia Mendez-Otero - Universidade Federal do Rio de Janeiro
Paulo H. Rosado-de-Castro - D’Or Institute for Research and Education
Pedro M. Pimentel-Coelho - Universidade Federal do Rio de Janeiro
Resource Type: Journal article
Publication Details: Frontiers in microbiology, Vol.8, p.1554
DOI: 10.3389/fmicb.2017.01554
PMID: 28878742
PMCID: PMC5572254
NLM abbreviation: Front Microbiol
ISSN: 1664-302X
eISSN: 1664-302X
Publisher: Frontiers Media Sa
Number of pages: 25
Grant note: PR-d-C; PP-C ZIKA-BIO-2016-2; RTA2013-0013-C04-01-E; RTA2015-00009 / INIA; Instituto de Investigacion Agropecuaria (INIA); Spanish Government AGL2014-56518-JIN / MINECO; Spanish Government e-26/201.341/2016 / FAPERJ; Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ)
Language: English
Date published: 08/22/2017
Academic Unit: Radiology
Record Identifier: 9985143551302771

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