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Zika Virus
Journal article   Open access   Peer reviewed

Zika Virus

Lyle R. Petersen, Denise J. Jamieson, Ann M. Powers and Margaret A. Honein
The New England journal of medicine, Vol.374(16), pp.1552-1563
04/21/2016
DOI: 10.1056/NEJMra1602113
PMID: 27355409
url
https://doi.org/10.1056/NEJMra1602113View
Published (Version of record) Open Access

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Abstract

IN 1947, A STUDY OF YELLOW FEVER YIELDED THE FIRST ISOLATION OF A NEW virus, from the blood of a sentinel rhesus macaque that had been placed in the Zika Forest of Uganda.(1) Zika virus remained in relative obscurity for nearly 70 years; then, within the span of just 1 year, Zika virus was introduced into Brazil from the Pacific Islands and spread rapidly throughout the Americas.(2) It became the first major infectious disease linked to human birth defects to be discovered in more than half a century and created such global alarm that the World Health Organization (WHO) would declare a Public Health Emergency of International Concern.(3) This review describes the current understanding of the epidemiology, transmission, clinical characteristics, and diagnosis of Zika virus infection, as well as the future outlook with regard to this disease.
General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology

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