Zoledronate and ion-releasing resins impair dentin collagen degradation

A Tezvergil-Mutluay; R Seseogullari-Dirihan; V P Feitosa; F R Tay; T F Watson; D H Pashley; S Sauro

doi:10.1177/0022034514546043

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Zoledronate and ion-releasing resins impair dentin collagen degradation

Journal article

Open access

Peer reviewed

Zoledronate and ion-releasing resins impair dentin collagen degradation

A Tezvergil-Mutluay, R Seseogullari-Dirihan, V P Feitosa, F R Tay, T F Watson, D H Pashley and S Sauro

Journal of dental research, Vol.93(10), pp.999-1004

10/01/2014

DOI: 10.1177/0022034514546043

PMCID: PMC4212321

PMID: 25074494

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https://europepmc.org/articles/pmc4212321View

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Abstract

This study analyzed the amounts of solubilized telopeptides cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and C-terminal crosslinked telopeptide of type I collagen (CTX) derived from matrix-metalloproteinases (MMPs) and cysteine cathepsins (CTPs) subsequent to application of a filler-free (Res.A) or an ion-releasing resin (Res.B) to ethylenediaminetetraacetic acid (EDTA)-demineralized dentin with or without zoledronate-containing primer (Zol-primer) pre-treatment. The chemical modification induced following treatments and artificial saliva (AS) storage was also analyzed through attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Totally EDTA-demineralized specimens were infiltrated with Res.A or Res.B with or without Zol-primer pre-treatment, light-cured, and immersed in AS for up to 4 wk. ICTP release was reduced following infiltration with Res.B and further reduced when Res.B was used with Zol-primer; remarkable phosphate mineral uptake was attained after AS storage. CTX release was increased in Res.A- and Res.B-treated dentin. However, when Zol-primer was used with Res.A, the CTX release fell significantly compared to the other tested resin-infiltration methods. In conclusion, zoledronate offers an additional inhibitory effect to the ion-releasing resins in MMP-mediated collagen degradation. However, Zol-primer induces a modest reduction in CTX release only when used with resin-based systems containing no ion-releasing fillers.

Aluminum Compounds - pharmacology

Bone Density Conservation Agents - pharmacology

Calcium Compounds - pharmacology

Calcium Phosphates - pharmacology

Calcium Sulfate - pharmacology

Cathepsins - antagonists & inhibitors

Cathepsins - pharmacology

Collagen - drug effects

Collagen Type I - analysis

Dentin - drug effects

Diphosphonates - pharmacology

Edetic Acid - pharmacology

Humans

Hydrogen-Ion Concentration

Imidazoles - pharmacology

Materials Testing

Matrix Metalloproteinase Inhibitors - pharmacology

Matrix Metalloproteinases - pharmacology

Peptides - analysis

Resin Cements - pharmacology

Saliva, Artificial - chemistry

Silicates - pharmacology

Solubility

Spectroscopy, Fourier Transform Infrared

Tooth Demineralization - chemically induced

Zoledronic Acid

Details

Title: Subtitle: Zoledronate and ion-releasing resins impair dentin collagen degradation
Creators: A Tezvergil-Mutluay - University of Turku
R Seseogullari-Dirihan - Turku University Hospital
V P Feitosa - Universidade Federal do Ceará
F R Tay - Augusta University
T F Watson - King's College London
D H Pashley - Augusta University
S Sauro - Universidad Cardenal Herrera CEU
Resource Type: Journal article
Publication Details: Journal of dental research, Vol.93(10), pp.999-1004
Publisher: SAGE Publications
DOI: 10.1177/0022034514546043
PMID: 25074494
PMCID: PMC4212321
ISSN: 0022-0345
eISSN: 1544-0591
Grant note: R01 DE015306 / NIDCR NIH HHS R0I DE015306 / NIDCR NIH HHS
Language: English
Date published: 10/01/2014
Academic Unit: Operative Dentistry
Record Identifier: 9984655343902771

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