Journal article
beta(2)-Adrenergic receptor supports prolonged theta tetanus-induced LTP
Journal of neurophysiology, Vol.107(10), pp.2703-2712
05/01/2012
DOI: 10.1152/jn.00374.2011
PMCID: PMC3362273
PMID: 22338020
Abstract
Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee HK, Hell JW. beta(2)-Adrenergic receptor supports prolonged theta tetanus-induced LTP. J Neurophysiol 107: 2703-2712, 2012. First published February 15, 2012; doi:10.1152/jn.00374.2011.-The widespread noradrenergic innervation in the brain promotes arousal and learning by molecular mechanisms that remain largely undefined. Recent work shows that the beta(2)-adrenergic receptor (beta(2)AR) is linked to the AMPA-type glutamate receptor subunit GluA1 via stargazin and PSD-95 (Joiner ML, Lise MF, Yuen EY, Kam AY, Zhang M, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW. EMBO J 29: 482-495, 2010). We now demonstrate that the beta(2)AR plays a prominent role in long-term potentiation (LTP) induced by a train of 900 stimuli at 5 Hz (prolonged theta-tetanus-LTP, or PTT-LTP) in the hippocampal CA1 region in mice, which requires simultaneous beta-adrenergic stimulation. Although PTT-LTP was impaired in hippocampal slices from beta(1)AR and beta(2)AR knockout (KO) mice, only beta(2)AR-selective stimulation with salbutamol supported this PTT-LTP in wild-type (WT) slices, whereas beta(1)AR-selective stimulation with dobutamine (+ prazosin) did not. Furthermore, only the beta(2)AR-selective antagonist ICI-118551 and not the beta(1)AR-selective antagonist CGP-20712 inhibited PTT-LTP and phosphorylation of GluA1 on its PKA site S845 in WT slices. Our analysis of S845A knockin (KI) mice indicates that this phosphorylation is relevant for PTT-LTP. These results identify the beta(2)AR-S845 signaling pathway as a prominent regulator of synaptic plasticity.
Details
- Title: Subtitle
- beta(2)-Adrenergic receptor supports prolonged theta tetanus-induced LTP
- Creators
- Hai Qian - University of IowaLucas Matt - University of California, DavisMingxu Zhang - University of California, DavisMinh Nguyen - Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USATommaso Patriarchi - University of California, DavisOlha M. Koval - University of IowaMark E. Anderson - University of IowaKaiwen He - University of Maryland, College ParkHey-Kyoung Lee - University of Maryland, College ParkJohannes W. Hell - University of California, Davis
- Resource Type
- Journal article
- Publication Details
- Journal of neurophysiology, Vol.107(10), pp.2703-2712
- Publisher
- Amer Physiological Soc
- DOI
- 10.1152/jn.00374.2011
- PMID
- 22338020
- PMCID
- PMC3362273
- ISSN
- 0022-3077
- eISSN
- 1522-1598
- Number of pages
- 10
- Grant note
- R01HL062494 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 11POST7020009 / American Heart Association HL-079031; HL-62494; HL-70250; R01-EY-014882; NS-035563; AG-017502 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AG017502 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01NS035563 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01EY014882 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Language
- English
- Date published
- 05/01/2012
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359675202771
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