Journal article
cAMP-related second messenger pathways modulate hearing function in Aedes aegypti mosquitoes
iScience, Vol.28(9), 113202
09/19/2025
DOI: 10.1016/j.isci.2025.113202
PMCID: PMC12357097
PMID: 40822900
Abstract
The powerful ears of male Aedes aegypti mosquitoes facilitate identification and localization of mating partners via detection of female flight tones. Male hearing function is modulated by the efferent release of neurotransmitters, though the secondary mechanisms underlying this modulation remain unclear. Here, we investigated these mechanisms using octopamine as a model, as octopamine modulates hearing function and the erection status of fibrillar hairs lining male ears. We found that pharmacological interference with octopamine receptors alters hearing function at multiple levels and identified the second messenger cAMP as likely mediating these changes. Furthermore, the erection status of male ear fibrillar hairs could be altered by targeting specific sub-types of octopamine receptors, but these changes were not linked to changes in ear frequency tuning. Finally, we suggest that octopamine α2 receptors linked to fibrillar hair erection may not always produce functional proteins across species, with downstream implications for hearing behaviors.
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•Octopamine and its receptors are found throughout Aedes aegypti mosquito ears•Pharmacological interference with octopamine receptors modulates hearing function•Modulating levels of the second messenger cAMP also alters hearing function•Ear frequency tuning does not correlate with the erection of hairs lining male ears
Details
- Title: Subtitle
- cAMP-related second messenger pathways modulate hearing function in Aedes aegypti mosquitoes
- Creators
- YiFeng Y.J. Xu - Nagoya UniversityYuMin M. Loh - Nagoya UniversityTai-Ting Lee - Nagoya UniversityWan-Tze Chen - Nagoya UniversityWenWei Loh - Nagoya UniversityTakuro S. Ohashi - Nagoya UniversityDaniel F. Eberl - University of IowaMarta Andrés - University College LondonMatthew P. Su - Nagoya UniversityAzusa Kamikouchi - Nagoya University
- Resource Type
- Journal article
- Publication Details
- iScience, Vol.28(9), 113202
- DOI
- 10.1016/j.isci.2025.113202
- PMID
- 40822900
- PMCID
- PMC12357097
- NLM abbreviation
- iScience
- ISSN
- 2589-0042
- eISSN
- 2589-0042
- Publisher
- Elsevier Inc
- Grant note
- JST FOREST: JPMJFR2147 Tokai Pathways to Global Excellence (T-GEx), MEXT Strategic Professional Development Program for Young Researchers: 0121an0002 MEXT KAKENHI Grant-in-Aid for Research Activity Start-up: JP22K15159 JSPS Short-term fellowship: PE19013 JSPS Invitational Fellowships for Research in Japan: S22091 International Principal Investigator (PI) Invitation Program, Nagoya University, JapanHuman Frontier Science Program Organization: RGP0033/2021
This study was financially supported by JST FOREST (No. JPMJFR2147 to A.K.) , Tokai Pathways to Global Excellence (T-GEx) , part of the MEXT Strategic Professional Development Program for Young Researchers (0121an0002 to M.P.S.) , MEXT KAKENHI Grant-in-Aid for Research Activity Start-up (No. JP22K15159 to M.P.S.) , JSPS Short-term fellowship (PE19013 to M.P.S.) , JSPS Invitational Fellowships for Research in Japan (Short-term) (S22091 to D.F.E.) , International Principal Investigator (PI) Invitation Program, Nagoya University, Japan (to D.F.E.) and the Human Frontier Science Program Organization (no. RGP0033/2021 to A.K.) .
- Language
- English
- Electronic publication date
- 07/24/2025
- Date published
- 09/19/2025
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984937944202771
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